The Epigenetics Group a part of the Center for Applied Bioinformatics (CAB) at St. Jude Childrens Research Hospital is seeking a highly motivated and creative Bioinformatics Research Scientist or Lead Bioinformatics Analyst. This position involves developing and applying innovative analytical approaches to uncover the mechanisms driving pediatric cancers and other human diseases. By contributing to a wide range of projects and assisting researchers across St. Jude you will make a meaningful impact on science and ultimately on the care and survival of pediatric cancer patients.
In addition to performing diverse analytical tasks we encourage team members to engage in pipeline development explore novel trends in the field stay updated on the latest methods and even create new methodologiesprovided these efforts align with our ultimate goal: Finding cures. Saving children.. Our work often leads to highprofile publications offering significant opportunities for career growth and scientific contributions.
What We Offer:
CAB provides a highly interactive and collaborative environment with opportunities to work alongside experts in transcriptomics genomics and genetics as well as across basic and clinical research departments. Resources include but are not limited to:
Access to St. Judes highperformance computing clusters and cloud computing sequencing platforms such as longread sequencing technologies singlecell DNA/RNA sequencing and spatial transcriptomics. Innovative visualization tools and highly automated analytical pipelines powered by GPU technology. Mentorship from experienced scientists in data analysis and management with an expertise in delivering highquality results for competitive projects. Opportunities to participate in and present at scientific conferences enhancing your expertise and expanding your network.
CAB members have opportunities to contribute to highimpact research coauthor prominent publications and file patents for novel biomarker discoveries or innovative methods in clinical diagnosis and treatment.
Job Responsibilities:
- Independently perform basic and advanced level statistical analysis algorithm implementation programming from a variety of biotechnology platforms and oversee quality check.
- Design and prepare materials and courses for training on various bioinformatics software and databases computing data mining and analysis.
- Act as a liaison between endusers software developers system designers and different departments.
- Establish protocols or best practices for common research tasks and SOP evaluate products and solutions to make recommendations and integrate solutions.
- Lead the development implementation installation and maintenance of databases; coordinate data collection database implementation and usage and any hardware and software related to database collection.
- Develop programs to assist in the analysis of data within the databases.
- Assist in planning coordinating and organizing projects across departments and delegate tasks based on priority expertise and capacity.
- Perform other duties as assigned to meet the goals and objectives of the department and institution.
- Maintains regular and predictable attendance.
Minimum Education and/or Training:
- Bachelors degree in bioinformatics cheminformatics statistics/computer science (with a background in biological sciences or chemistry) or related field.
- Masters degree or PhD preferred.
Minimum Experience:
- Minimum Requirement: Bachelors degree with 6 years of relevant postdegree work in bioinformatics cheminformatics statistics/computer science (with a background in biological sciences or chemistry).
- Experience Exception: Masters degree with 4 years of relevant postdegree experience (OR) PhD with no experience.
- Experience in at least one programming or scripting language and at least one statistical package with R preferred.
Qualifications:
Ideal candidates will have:
- Experience building maintaining and optimizing analysis pipelines or installing tools for highthroughput nextgeneration sequencing data analysis (e.g. ChIPSeq ATACSeq RNASeq HiC HiChIP or CaptureC) in Linux/Unix environments.
- A solid understanding of basic epigenetic gene regulation mechanisms like histone modifications chromatin accessibility DNA methylation or the 3D genome.
- Very good programming skills in Bash scripting language and Python (preferred) or R programming languages.
- Experience with version control systems such as Git.
- Strong communication and project managements skills.
- Experience with deep learning and Nextflow is a plus.
This is an exceptional opportunity to gain experience in diverse areas of bioinformatics contribute to cuttingedge research and play a vital role in advancing St. Judes mission.
Responsibilities
- Specific responsibilities may include NGS data quality control multiomics integrative analyses data visualization and the development and evaluation of analytic tools. Excellent communication skills are essential. You will collaborate closely with various St. Jude Principal Investigators and their research teams to provide standardized or customized analyses utilizing St. Judes highperformance computing clusters and cloud computing environments.
Additional Requirements:
- Proficiency in programming (e.g. Python R C/C Perl or other programming/scripting languages) in Linux/Unix environments is required.
- Proven ability to work effectively with a wide range of users.
- Demonstrated experience in analyzing and interpreting epigenetics data.
- Proven experience conducting independent data analyses and managing projects is required.
- Experience providing enduser support and training is required.
Compensation
In recognition of certain U.S. state and municipal pay transparency laws St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets experience and training licensure and certifications and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $86320 $154960 per year for the role of Bioinformatics Research Scientist Epigenetics Group.
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