Postdoctoral Fellow-MSH
Postdoctoral Fellow-MSH
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Job Description
Strength Through Diversity
Ground breaking science. Advancing medicine. Healing made personal.
Roles & Responsibilities:
Multiple postdoctoral positions are immediately available in Shi laboratory of Proteomics Center for Protein Engineering and Therapeutics at Icahn School of Medicine at Mount Sinai in NYC
The lab is interested in developing biotechnologies for the analysis of biomolecules and macromolecular assemblies with a focus on mass spectrometry/proteomic techniques. Recently inspired by the high translational potential of the camelid singlechain antibodies (so called nanobodies) our lab has developed robust pipeline technologies and tools to facilitate nanobody drug discovery and therapeutic applications. The lab is also interested in the development and application of integrative structural approaches to study proteinprotein and antibodyprotein interactions. An emerging direction of the lab is to conjugate machine learning structural biology and proteomic approaches to facilitate engineering and design towards novel protein therapeutics and vaccine development. The lab is vibrant fun and collaborative and support creative ideas and career development.
References:
Kim S.J. et al 2018. Integrative structure and functional anatomy of a nuclear pore complex. Nature.
Xiang Y. et al 2020. Versatile and multivalent nanobodies efficiently neutralize SARSCoV2. Science.
Nambulli. et al 2021. Inhalable Nanobody (PiN21 prevents and treats SARSCoV2 infections in Syrian hamsters at ultralow doses. Science Advances.
Xiang Y. et al 2021. Integrative proteomics identifies thousands of distinct multiepitope and highaffinity nanobodies. Cell Systems.
Sun et al. 2021. Potent neutralizing nanobodies resist convergent circulating variants of SARSCoV2 by targeting novel and conserved epitopes. Nature Communications.
Shen et al. 2021. A resource of highquality nanobodies for drug delivery. iScience.
Sang et al. 2021 Llamanade: an opensource computational pipeline for robust nanobody humanization. Structure.
Xiang et al 2022. Superimmunity by broadly protective nanobodies to sarbecoviruses. BioRxiv.
The lab is funded by multiple grants including the NIH AAZ and MJFF. Competitive salaries can be provided for successful candidates.
Visit our lab at:
Some related news are list here:
Inhaled nanobodies effective against coronaviurs in hamsters researchers say (Fox News)
Llama nanobodies may yield COVID19 treatment Pitt scientists say (The Philadelphia Inquirer)
Why the lovable llama might be a secret weapon against COVID19 (Argonne National Library)
https://pittnews/article/161919/topstories/pittresearchersfindcovid19breakthroughinllamananobodies/
Nasal spray gives Pitt researchers a promising new weapon to fight COVID (Next Pittsburgh)
Pitt Researchers Discover Llama Nanobodies Are Powerful New Coronavirus Treatment (CBS Local)
Pitt team discovers new way to find nanbodies to fight disease (WPXI)
Pitt scientists unveil potential powerful treatment for COVID19 using llama nanobodies (WJAC)
Pitt researchers say llamas may help research and treatment of COVID (WTAE)
Alpacas and llamas may hold the key to alternative COVID19 vaccine (Fox 8
Llama antibodies Why researchers say they could be powerful weapon against COVID19 (ABC 7
Researchers hope to harness power of llama nanobodies to treat coronavirus (Fox 43
Inhaled antibody fragments protect infected animals against COVID19 (The Scientist)
Inhalable nanobody shows potent antiSARSCoV2 activity in vivo (Medical)
Scientists Cure COVID in Hamsters With Inhaled Nanobodies: Study (Gadgets 360
Llama nanobodes are a powerful bew COVID19 treatment: Study (The New York Post)
Asthma style inhalter of tiny nanobodies cleared COVID infection in hamsters (Daily Mail UK)
Inhaled COVID Meds and Simple SelfAdministered Care (Medscape)
Neutralizing nanobodies effective against SARSCoV2 variants (Medical)
Requirements:
Motivated individuals (PhD or MD) with a background in mass spectrometrybased proteomics microbiology structural biology (such as cryoEM) and cancer immunology (ideally with animal model experience) are particularly welcome to apply. Interested candidates may submit their CV including names and contact information for twothree references a short description of their research experience and goals to Yi Shi at .
Strength Through Diversity
The Mount Sinai Health System believes that diversity equity and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient you join us you become a part of Mount Sinais unrivaled record of achievement education and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by:
- Using a lens of equity in all aspects of patient care delivery education and research to promote policies and practices to allow opportunities for all to thrive and reach their potential
- Serving as a role model confronting racist sexist or other inappropriate actions by speaking up challenging exclusionary organizational practices and standing sidebyside in support of colleagues who experience discrimination
- Inspiring and fostering an environment of antiracist behaviors among and between departments and coworkers
We work hard to acquire and retain the best people and to create an inclusive welcoming and nurturing work environment where all feel they are valued belong and are able to professionally advance. We share the belief that all employees regardless of job title or expertise contribute to the patient experience and quality of patient care.
Explore more about this opportunity and how you can help us write a new chapter in our history!
Who We Are
Over 42000 employees strong the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education research and outreach in the many diverse communities we serve.
Formed in September 2013 The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospitals including Mount Sinai Beth Israel Mount Sinai Brooklyn The Mount Sinai Hospital Mount Sinai Queens Mount Sinai West (formerly Mount Sinai Roosevelt) Mount Sinai St. Lukes and New York Eye and Ear Infirmary of Mount Sinai.
The Mount Sinai Health System (MSHS) provides equal employment opportunity to all its employees and applicants for employment without unlawful discrimination on the basis of their actual or perceived race creed color religion national origin sex gender gender expression gender identity age disability marital or parental status sexual orientation veteran immigration citizenship or other protected status.
EOE including Veterans and Disabled
Employment Type
Full-Time
