Manager Clinical PharmacologyQuantitative Pharmacology

When we put unexpected teams in the same room we unleash bold thinking with the power to inspire lifechanging medicines. Inperson working gives us the platform to connect work at pace and challenge perceptions. Thats why we work on average a minimum of three days per week from the office. But that doesnt mean were not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

The Manager Clinical Pharmacology/Quantitative Pharmacology (CPQP) position is responsible for supporting data analyses modeling & simulation (M&S) and document writing activities at all Phases of drug development. The focus is to propose and confirm the posology for Alexions developed medicines. The incumbent will coordinate multiple projects and be encouraged to complete activities independently or through management of external CROs. The position requires onsite participation on cross functional drug development teams where discussions and presentations to program teams and governance bodies is expected. Finally this role is key in strengthening the CPQP capability within Alexion by contributing to continuous improvement of pharmacometrics technical skills computational infrastructure and the strategic use of M&S methodologies across our programs and disease areas.

Key Responsibilities:

• Leading CPQPrelated projects on one or more cross functional development teams developing and implementing M&S strategies/plans fully coordinated with overall preclinical and clinical plans. These projects will include (but are not limited to) NCA population PK PKPD analyses clinical trial simulations and other modelbased analyses when appropriate.
• Introducing new M&S techniques to greatly enhance decisionmaking during key breakthroughs relying on quantitative principles in close collaboration with other quantitative subject areas.
• When needed initiate and coordinate outsourced M&S activities.
• Preparing population PK/PD reports and corresponding regulatory submission documents.

Essential Education Experience & Skills:

• A PhD degree or equivalent in a quantitative science
• 1 years pharmaceutical industry or equivalent experience in a related discipline such as clinical pharmacology engineering math/statistics or computer science.
• Excellent handson knowledge in R Julia Python NONMEM (or other NLME software).
• Excellent knowledge in Matlab or other QSP related software.
• Well versed at plotting complex data to identify trends important for drug development.
• The duties of this role are generally conducted in an office environment. As is typical of an officebased role employees must be able with or without an accommodation to: use a computer; engage in communications via phone video and electronic messaging; engage in problem solving and nonlinear thought analysis and dialogue; collaborate with others; maintain general availability during standard business hours.

Desirable Experience & Skills:

• Experience in the application of mathematical modeling to hematology nephrology and/or neurological disorders and rare diseases.

Date Posted

Closing Date

Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness. The Company will not make decisions about employment training compensation promotion and other terms and conditions of employment based on race color religion creed or lackthereof sex sexualorientation age ancestry national origin ethnicity citizenship status marital statuspregnancy (including childbirth breastfeeding or related medical conditions) parental status (including adoption or surrogacy) military status protected veteran status disability medical condition gender identity or expression genetic information mental illness or other characteristics protected by law. Alexion provides reasonable accommodations to meet the needs of candidates and employees. To begin aninteractive dialogue with Alexion regarding an accommodation please contact . Alexion participates in EVerify.