Senior Scientist Translational
Senior Scientist Translational
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Job Description
Overview
The Senior Scientist will perform experiments aimed at identifying biomarkers and mechanism of action of tumorinfiltrating lymphocyte (TIL) therapy and serve as Translational representative in multifunctional teams. The successful candidate may also manage guide or mentor one or more research associates or junior scientists.
Essential Functions and Responsibilities
- Lead and supervise one or more research projects aimed at identifying correlates of TIL clinical activity or mechanism of action.
- Design and execute research experiments involving a variety of protocols and techniques. Methods may include identification and functional assessment T cells gene expression studies on TIL and tumor biopsies and characterization by flow cytometry NGS or other methods.
- Analyze and interpret experimental results. Make detailed observations and record them in a timely and relevant fashion.
- Work with bioinformatic experts to identify immune correlates of TIL clinical activity
- Investigate and develop new methods and technologies necessary for project advancement
- Present experimental results in written documents and oral presentations in internal and external meetings
- Manage interactions with contract research organizations providing bioassay services
- Provide oversight and training to teammates
- Act as the Translational representative on clinical study management teams facilitate drafting Translational plans clinical protocols lab manuals.
- Maintain a high level of professional expertise through regular survey of scientific literature and attendance of training and/or scientific seminars
- Contribute to Regulatory documents and scientific publications
- Comply with Safety SOPs SDS sheets and laboratory procedures per company policy and OSHA regulations
- Other duties as assigned
Required Education Skills and Knowledge
- PhD in Immunology Cellular Biology or related discipline required
- 8 years of combined postdoctoral training and industry experience.
- Knowledge of immunooncology or immune mechanisms is required
- Prior experience working biomarker plans on clinical trials is required.
- Ability to independently carry out all lab experiments
- Strong interpersonal skills including effective verbal and written communication skills
- Excellent record keeping and organizational skills
Preferred Education Skills and Knowledge
- Experience with in vitro T cell functional assays flow cytometry staining and acquisition techniques is a plus.
- Prior experience working with human T cells and PBMC is preferred.
- The physical demands described here represent those that an employee must meet to perform the essential functions of this job successfully. Reasonable accommodations may be made upon request to enable individuals to perform essential functions. Please contact Human Resources to request an accommodation.
Physical Demands and Activities Required
- Must be able to move to and from the office to the lab located on separate floors and move about the office and lab as needed.
- Must be able to remain in a stationary position standing or sitting for prolonged periods of time.
- Must be able to grasp with both hands perform repetitious actions such as pinch with thumb and forefinger turn with hand/ arm and reach above shoulder height.
- Must be able to use several types of laboratory equipment and pipettes for extended periods.
- Must be able to work on a tablet or computer typing for 50 of a typical working day.
- Must be able to move and lift 20 pounds multiple times daily.
- Must be able to use near vision to view samples at close range.
- Wear proper personal protective equipment such as safety glasses lab coats and closedtoed shoes when in a laboratory setting.
Mental: Clear and conceptual thinking ability; excellent judgment troubleshooting problemsolving analysis and discretion; ability to handle workrelated stress; ability to handle multiple priorities simultaneously; and ability to meet deadlines
Work Environment
This position will work in both an office and a laboratory setting. When in the lab there may be a risk of exposure to hazardous or biological waste within the environment through receipt transport storage preparation dispensing administration cleaning and/or disposal of contaminated areas and waste. Depending on experiments or project deadlines working evenings holidays or weekends may occasionally be required.
The statements contained in this document are intended to describe the general nature and level of work being performed by a colleague assigned to this description. They are not intended to constitute a comprehensive list of functions duties or local variances. Management retains the discretion to add or change the positions responsibilities at any time.
Iovance is committed to cultivating and offering a diverse and inclusive work environment. As an equalopportunity employer our employees and applicants will be considered without regard to an individuals race color religion sex pregnancy national origin age physical and mental disability marital status sexual orientation gender identity gender expression genetic information military and veteran status and any other characteristic protected by applicable law. If you need assistance or accommodation to apply to one of our opportunities please get in touch with .
By voluntarily providing information and clicking Submit Application you explicitly consent to the collection and use of your personal information for the purposes described above and in ourCandidate Privacy Notice.
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Required Experience:
Senior IC
Employment Type
Full-Time
