Senior Research Associate
Senior Research Associate
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Job Description
Overview
The Senior Research Associate will work on developing methods to optimize the antitumor activity of tumorinfiltrating lymphocytes (TILs) for therapeutic applications. Such methods may include ex vivo manipulation of T cell costimulatory and coinhibitory pathways setting up screening assays generation of patientderived tumor organoids (tumoroids) to study TIL function as well as developing genetically engineered TILs with enhanced vivo persistence and therapeutic activity.
Essential Functions and Responsibilities
- Tissue Processing: Process primary tumor samples to generate autologous tumorinfiltrating lymphocytes (TIL) to be used for downstream assays.
- Assay : Design and implement coculture assays to assess TIL function using a variety of techniques; utilize viral techniques to label primary cancer cells and TIL for tracking in vitro
- Model Development: Develop and maintain patientderived tumor organoids and 3D cell lines
- Translational Assays: Perform complex 2D and 3D assays that contribute to our understanding of TIL mechanism of action
- Data Management: Analyze experimental data and present results at team meetings for discussion
- Team Collaboration: Conducts experiments under overall direction of the Senior Director and/or more senior scientist; Ability to track and execute multiple projects at once.
- Conduct: Must adhere to Iovance Biotherapeutics core values policies procedures and business ethics. Comply with Safety SOPs SDS sheets and laboratory procedures per company policy and OSHA regulations.
- Perform miscellaneous duties as assigned.
Required Education Skills and Knowledge
- Masters Degree in Cellular Biology Molecular Biology Immunology or related discipline with 6 or more years of relevant bench research experience preferably in industry
- Expertise with development and longterm maintenance of patientderived tumor organoids
- Extensive tissue culture experience using primary T cells familiarity with in vitro T cell functional assays flow cytometry staining and acquisition techniques expected.
- Understanding of and experience with molecular biology techniques including DNA and RNA extractions PCR plasmid cloning and generation of various viral vectors.
- Excellent recordkeeping and organization skills and effective communicator (verbal and written).
- Comfortable working independently and as part of a team.
The physical demands described here represent those that an employee must meet to perform the essential functions of this job successfully. Reasonable accommodation may be made upon request to enable individuals to perform essential functions. Please contact Human Resources to request accommodation.
Physical Demands and Activities Required
- Must be able to move to and from the office to the lab located on separate floors and move about the office and lab as needed.
- Must be able to remain in a stationary position standing or sitting for prolonged periods of time.
- Must be able to grasp with both hands perform repetitious actions such as pinch with thumb and forefinger turn with hand/ arm and reach above shoulder height.
- Must be able to use several types of laboratory equipment and pipettes for extended periods.
- Must be able to work on a tablet or computer typing for 50 of a typical working day.
- Must be able to move and lift 20 pounds multiple times daily.
- Must be able to use near vision to view samples at close range.
- Wear proper personal protective equipment when in a laboratory setting i.e. safety glasses lab coats and closedtoed shoes.
Mental: Clear and conceptual thinking ability; excellent judgment troubleshooting problemsolving analysis and discretion; ability to handle workrelated stress; ability to handle multiple priorities simultaneously; and ability to meet deadlines.
Work Environment
This position will work in both an office and a laboratory setting. When in the lab there may be a risk of exposure to hazardous or biological waste within the environment through receipt transport storage preparation dispensing administration cleaning and/or disposal of contaminated areas and waste.
The statements contained in this document are intended to describe the general nature and level of work being performed by a colleague assigned to this description. They do not constitute a comprehensive list of functions duties or local variances. Management retains the discretion to add or to change the duties of the position at any time.
Iovance is committed to cultivating and offering a diverse and inclusive work environment. As an equalopportunity employer our employees and applicants will be considered without regard to an individuals race color religion sex pregnancy national origin age physical and mental disability marital status sexual orientation gender identity gender expression genetic information military and veteran status and any other characteristic protected by applicable law. If you need assistance or accommodation to apply to one of our opportunities please contact .
By voluntarily providing information and clicking Submit Application you explicitly consent to the collection and use of your personal information for the purposes described above and in our Candidate Privacy Notice.
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Required Experience:
Senior IC
Employment Type
Full-Time
