Research ScientistSenior Research Scientist BiologicsImmunology
Research ScientistSenior Research Scientist BiologicsImmunology
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$ 90000 - 130000
1 Vacancy
Job Description
Position Title:Research Scientist/Senior Research Scientist Biologics/ImmunoOncology
Position Summary
Calibr is seeking a talented Research Scientist in the area of immunooncology. This position will work as part of a small team of interdisciplinary scientists to translate innovative cell and protein therapies for the treatment of cancer into firstinhuman clinical trials. Specifically projects will be focused on the development of next generation T cellrecruiting antibodies (bi/multi specific antibodies) and switchable chimeric antigen receptor T (CART). Both platform technologies have the potential to have curative responses for cancer patients. While working within the scope of these projects this position will also have the unique opportunity to be exposed to a wide range of other projects at Calibr covering infectious and neglected tropical diseases metabolic disorders autoimmunity and others. Calibrs open lab space design and collaborative environment encourages the seamless flow of ideas within and between research groups. This position will receive hands on training in translational research and gain knowledge on how scientific ideas are translated into to help patients in need. The ideal candidate is expected to bring the basic scientific proficiencies listed below at the start. This position offers significant growth opportunity through promotion structures designed to retain exceptional talent within the Calibr family. This position will require training and managing entry level Research Associates with increased responsibility over time.
Essential Duties and Responsibilities
- Design and of project plans involving characterization of signaling pathways phosphoflow immune cell profiling cell processing from xenograft models cytotoxicity proliferation activation and survival assays with a strong focus on flow cytometry and ELISA.
- Cell biology including working (isolation characterization and assay set up) with primary human and murine cells immune and tumor cell lines used in immunooncology research and primary patientderived cells.
- Design characterization and development of antibodies including bi and multispecific antibodies.
- Molecular biology experiments including DNA and protein preparation from cells immunoprecipitation western blots etc will be within the scope of work.
- Gene editing of primary human immune cells using state of the art technologies like CRISPR TALEN and other endonucleases while using multiple delivery approaches including protein and mRNA electroporation and multiple viral vector platforms.
- Preparation of reports and presentation of results at regular team meetings.
Qualifications and Experience
- A strong background in immunology is essential (Experience in T/B/NK/macrophage cell biology autoimmune disease and tumor immunology).
- Handson experience within vitro assays (coculture signaling activation assays)is essential.
- A strong background in cell culture and multicolor flow cytometry is essential.
- Knowledge and handson expertise in protein engineering antibody design and characterization are important.
- Experience withmolecular biology techniques is important.
- Experience withgene editing celltransfectionandtransductionsystems is preferred but not required.
- Experience preparing reagents forin vivoassays andIn vivo studyexperiencepreferred but not required.
- Experience using Prism FlowJo Office and JMP software is important.
- Details of established essential functions for this position will be addressed/discussed during the interview process.
Requirements
- Bachelors degree in biology chemical biology biochemistry or related field required. PhD is highly preferred.
- Minimum 2 years experience in the industry required.
- Impeccable attention to detail and excellent ability to perform handson experiments research design and organize project designs and maintain detailed documentation.
- Highly motivated creative and devoted to project goals.
- Able to collaborate proficiently and communicate effectively with colleagues and management teams.
- Able to contribute in a meaningful way to scientific discourse.
Physical Requirements:
This position works in a laboratory environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.
COMPENSATION
The expected hiring range for this position is $90000.00 to $130000.00 commensurate with experience.
COMPREHENSIVE BENEFITS INCLUDE
- Employer Contributed Retirement Plan Depending on eligibility employees receive an employer contributed retirement plan (no employee contribution required) and the option to contribute to a 403(b) (which is similar to a 401(k) using your own pre or posttax dollars)
- Full Suite of Health and Welfare plans including three medical plan options (including an HSA available option) dental vision life insurance disability EAP and more
- Access to Flexible Spending Accounts (Medical/Dependent Care)
- Competitive vacation and sick leave policies
- Free onsite parking
The above statements describe the level of work performed and expected in general terms. The statements are not intended to list all the responsibilities duties and/or skills required of employees so classified and the content herein is subject to change due to the business needs of Scripps Research with or without notice. Furthermore nothing in this job description shall be interpreted to be in conflict with or to eliminate or modify in any way the employmentatwill status of Scripps Research staff.
EEO Statement:
The Scripps Research Institute is an Equal Opportunity Employer. We promote diversity of thought culture and background in the fields of science. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race color religion sex sexual orientation gender identity national origin disability protected veteran status or any other legally protected characteristic or status.
Required Experience:
Senior IC
Employment Type
Full-Time
