Postdoctoral Research Associate Systemic Immunity and Growth-Defense Trade-offs
Postdoctoral Research Associate Systemic Immunity and Growth-Defense Trade-offs
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Job Description
Brookhaven National Laboratory is committed to employee success and we believe that a comprehensive employee benefits program is an important and meaningful part of the compensation employees receive. Review more information at BNL Benefits Program
ORGANIZATIONAL OVERVIEW
Researchers in the Biology Department at Brookhaven National Laboratory (BNL) work to unravel the complexities of biological systems from how plants make oils to the role of proteins in disease. Our work helps to develop and apply novel tools in biochemistry genetics cell and structural biology and bioimaging. We also leverage the unique capabilities of BNLs National Synchrotron Light SourceII (NSLSII) Laboratory for Biomolecular Structure (LBMS) cryoEM facility and Center for Functional Nanomaterials (CFN) which serve scientists worldwide. Our research supports the missions of the U.S. Department of Energys (DOE) Office of Sciences and the DOE Office of Biological and Environmental Research. Together with the ColliderAccelerator Department we also manage the NASA Space Radiation Laboratory studying space radiation effects on living and nonliving systems.
JOB DESCRIPTION
The Biology Department at BNL is seeking a highly motivated Postdoctoral Research Associate to investigate the molecular basis of plantpathogen interactions in bioenergy Sorghum. The successful candidate will study plant immune responses at the organismal subcellular and molecular levels to uncover novel genetic pathways regulating local and systemic acquired resistance as well as growthdefense tradeoffs. Using bacterial fungal and viral disease models the research will focus on identifying and characterizing essential immune regulators that promote host cell survival and orchestrate induction of defense genes in coordination with growth processes across diverse diseases and environmental stresses.
This project is part of the newly established Plant Immunity Research Initiative (PIRI) a DOEfunded program aimed to resolve devastating diseases that affect bioenergy crops. PIRIs mission is to develop resilient bioenergy crops without reducing their growth to promote sustainable bioenergy production.
The position will provide exceptional opportunity for research using advanced techniques in molecular and cell biology biomolecular phase separation genomics bioinformatics and bioimaging. Bioimaging tools include superresolution confocal microscopy Xray fluorescence microscopy and CryoEM. Molecular tools include mass spectrometry protein chromatography biochemical methods to study protein phase separation. The candidate will benefit from stateoftheart research facilities at BNL including latest Airyscan superresolution confocal microscope; NSLSIIs Xraybased microscopes; CFNs single molecule FLIM/FRET system; LBMSs electron microscopes for cryoEM tomography; and highperformance computational resources for data analysis.
This position offers a dynamic collaborative environment engaging with experts across plant biology microbiology structural biology and computational sciences and has a high level of interaction with an international and multicultural scientific community.
Essential Duties and Responsibilities:
Conduct plant inoculations with fungal bacterial and viral pathogens collect tissue samples and quantify disease.
Perform genomic and proteomic analyses of immune responses in resistant and susceptible plantpathogen interactions.
Clone genes produce proteins and conduct affinity purification chromatography phase analysis SDSPAGE and immunoblotting.
Design and implement advanced CRISPRCas9based genome editing including prime editing to understand immune gene function.
Perform highresolution live imaging to study cellular and subcellular events during hostpathogen interaction.
Publish research findings in peerreviewed journals and present at scientific conferences.
Required Knowledge Skills and Abilities:
Ph.D. in plant biology microbiology molecular biology cell biology genetics biochemistry immunology or a related field.
Experience with whole plant assays cell culture and molecular biology techniques.
Proven record of research publications in peerreviewed journals.
Strong communication skills with the ability to work collaboratively in a team environment.
Preferred Knowledge Skills and Abilities:
Bioinformatics skills (basic proficiency in MatLab Python or R).
Experience with light and electron microscopy including image analysis tools.
Experience in plant expression assays such as transient expression in plant leaves or protoplasts.
Background in proteinprotein interaction studies using bioluminescence fluorescence affinity purification and Kd measurements.
OTHER INFORMATION:
Review of applications begins immediately and will continue until the position is filled.
The initial appointment is for one year with annual renewal contingent on performance and funding.
Research is directed by Dr. Raul Zavaliev . Interested candidates should contact Dr. Zavaliev for detailed information about the research position.
Candidates must have their Ph.D. earned before the start of the employment.
BNL policy requires that candidates eligible for research associate appointments must not exceed a total of five years of relevant postdoctoral and/or R&D work experience after obtaining their Ph.D. excluding time taken for family planning military service illness or other lifechanging events.
BNL is committed to providing fair equitable and competitive compensation. The salary for this position is $71900/ year. Salary offers will be considered with the internal peer group.
The work will be conducted at BNL with full access to all the institutional and departmental computational resources services equipment and facilities.
Candidates should submit a CV and a cover letter that includes a brief description of their research interests.
About Us
Brookhaven National Laboratory () delivers discovery science and transformative technology to power and secure the nations future. Brookhaven Lab is a multidisciplinary laboratory with seven Nobel Prizewinning discoveries 37 R&D 100 Awards and more than 70 years of pioneering research. The Lab is primarily supported by the U.S. Department of Energys (DOE) Office of Science. Brookhaven Science Associates (BSA) operates and manages the Laboratory for DOE. BSA is a partnership between Battelle and The Research Foundation for the State University of New York on behalf of Stony Brook University. BSA salutes our veterans and active military members with careers that leverage the skills and unique experience they gained while serving our country learn more at BNL Opportunities for Veterans at Brookhaven National Laboratory.
Equal Opportunity/Affirmative Action Employer
Brookhaven Science Associates is an equal opportunity employer that values inclusion and diversity at our Lab. We are committed to ensuring that all qualified applicants receive consideration for employment and will not be discriminated against on the basis of race color religion sex sexual orientation gender identity national origin age status as a veteran disability or any other federal state or local protected class. BSA takes affirmative action in support of its policy and to advance in employment individuals who are minorities women protected veterans and individuals with disabilities. We ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process to perform essential job functions and to receive other benefits and privileges of employment. Please contact us to request accommodation. *VEVRAA Federal Contractor
BSA employees are subject to restrictions related to participation in Foreign Government Talent Recruitment Programs as defined and detailed in United States Department of Energy Order 486.1A. You will be asked to disclose any such participation at the time of hire for review by Brookhaven. The full text of the Order may be found at: Experience:
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Employment Type
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