Senior Scientist Vector Cell Line Development

Senior Scientist Vector and Cellline development

Summary:

Catalent Cell and Gene Therapy is looking to recruit a Senior Scientist Vector and Cellline development to join our growing team in Baltimore MD.

Catalent Inc. is a leading global contract development and manufacturing organization (CDMO) whose mission is to develop manufacture and supply products that help people live better and healthier lives. Catalent is dedicated to delivering unparalleled service to pharma biotech and consumer health customers supporting product development launch and full lifecycle supply. With timetested experience in development sciences delivery technologies and multimodality manufacturing Catalent supports the acceleration of development programs and the launch of more than a hundred new products every year. Powered by thousands of scientists and technicians and the latest technology platforms at more than 40 global sites Catalent supplies billions of doses of lifeenhancing and lifesaving treatments for patients annually.

The Viral Vector R&D Product Development Team supports development of AAV LVV viral therapies vector development cellline development Innovation areas including mRNA exosomes enzymes viral proteins. In addition the Innovation team participates in due diligence evaluation of partners vendors and potential acquisition targets. Within Biomodalities the C> business unit continues to develop technology inhouse and evaluates potential external offerings. The team also supports Master Cell Bank production Plasmid Master Banks and collaborates with Manufacturing Science and Technology (MS&T) to support tech transfer and provide investigation support to GMP. In addition novel technologies are progressed through a Catalent corporate initiative for creating integrated Platform offerings to our customers. People joining our team will have the opportunity for career development as our business continues to grow and expand.

The successful candidate will work with a team of scientists from Process Development to enable the delivery of lifechanging gene therapies to patients. The Senior Scientist Cellline development will be recognized as a technical expert and a scientific lead. He/she will be responsible for new technology evaluation development and implementation for improved workflows and systems. The candidate will be forecasting and planning resource requirements for projects assigned. Finally the successful candidate will undertake mentoring of team members to guide them in developing novel celllines and processes.

Catalent is committed to a Patient First culture through excellence in quality and compliance and to the safety of every patient consumer and Catalent employee.

This is a fulltime onsite position Monday Friday 8:00am5:00pm

The Role:

• Generate stable packaging and produce cell lines and clones for clinical and commercial programs for AAV and lentiviral vectors
• Design and evaluate novel plasmid vectors for optimal AAV and/or lentiviral yields along with improved packaging.
• Execute the cell line development programs to develop robust highly productive cell lines which encompass plasmid construction transfection cloning highthroughput platebased screening and of cell line screening experiments using a highthroughput ambr bioreactor system.
• Propose and execute technology improvements to the host cell line equipment and methods furthering their own skill sets while advancing the capabilities of the group.
• Evaluate novel cell transfection and cell activation/expansion strategies.
• Novel methods development to support new modalities for inprocess assays. Perform various immunological and cellbased assays to support client research.
• Must be a strong team player and can collaborate effectively on complex projects.
• Demonstrates capability to mentor junior colleagues in a team environment.
• Troubleshoot scientific and technical challenges and contribute to their resolution.
• Ensures effective and timely documentation in laboratory notebooks and internal Technical Reports.
• Other duties as assigned.

The Candidate:

• PhD degree in a biological or engineering discipline (biology biochemistry molecular biology or equivalent) with 7 years of experience OR
• MS degree in a biological or engineering discipline (biology biochemistry molecular biology or equivalent) with 9 years of experience
• Experience with a wider array of cell types to include HEK293 NK cells T NK Treg Mac TCR TIL and others is a plus.
• Sequencing approaches including PacBio ONT NGS experience is desired
• The successful candidate will possess strong oral and written communication skills.
• Experience with preparation of regulatory documents is a plus
• Excellent problem solving as well as and written/verbal communication skills
• Strong interpersonal skills and ability to work effectively on teams
• Routinely suggests new innovative solutions to routine and complex problems
• Experience with various celllines for recombinant protein and gene therapy vector expression process development and/or bioprocess manufacturing.
• Ability to execute detailed experimental plans record procedures analyze data and present results.

The anticipated salary range for this position in Maryland is $118720 $163240 plus anannual bonus when eligible. The final salary offered to a successful candidate may vary and will be dependent on several factors that may include but are not limited to: the type and length of experience within the job type and length of experience within the industry skillset education business needs etc. Catalent is a multistate employer and this salary range may not reflect positions that work in other states.

Why You Should Join Catalent:

• Defined career path and annual performance review and feedback process
• Diverse inclusive culture
• Potential for career growth on an expanding team within an organization dedicated to preserving and bettering lives
• 152 hours of paid time off annually 8 paid holidays
• Competitive salary with yearly bonus potential
• Community engagement and green initiatives
• Generous 401K match and Paid Time Off accrual
• Medical dental and vision benefits effective day one of employment
• Tuition Reimbursement

Catalent offers rewarding opportunities to further your career! Join the global drug development and delivery leader and help us bring over 7000 lifesaving and lifeenhancing products to patients around the world. Catalent is an exciting and growing international company where employees work directly with pharma biopharma and consumer health companies of all sizes to advance new medicines from early development to clinical trials and to the market. Catalent produces more than 70 billion doses per year and each one will be used by someone who is counting on us. Join us in making a difference.

personal initiative. dynamic pace. meaningful work.

Visit Catalent Careers to explore career opportunities.

Catalent is an Equal Opportunity Employer including disability and veterans.

If you require reasonable accommodation for any part of the application or hiring process due to a disability you may submit your request by sending an email and confirming your request for an accommodation and include the job number title and location to . This option is reserved for individuals who require accommodation due to a disability. Information received will be processed by a U.S. Catalent employee and then routed to a local recruiter who will provide assistance to ensure appropriate consideration in the application or hiring process.

Notice to Agency and Search Firm Representatives: Catalent Pharma Solutions (Catalent) is not accepting unsolicited resumes from agencies and/or search firms for this job posting. Resumes submitted to any Catalent employee by a third party agency and/or search firm without a valid written & signed search agreement will become the sole property of Catalent. No fee will be paid if a candidate is hired for this position as a result of an unsolicited agency or search firm referral. Thank you.

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