Research Associate Systems Biology Phage Therapy Gladstone Institute of Virology
Research Associate Systems Biology Phage Therapy Gladstone Institute of Virology
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Job Description
Category:
Science
Lab/Area:
Silas LabDescription:
Who we are:
The Gladstone Institutes is a distinguished independent notforprofit research institution dedicated to advancing human health through cuttingedge medical research and education. Our work spans neuroscience cardiovascular biology immunology and stem cell biology with a focus on overcoming disease. With a team of approximately 600 members including renowned leaders in science and biomedicine Gladstone operates across five institutes alongside various centers and programs. Located at the Mission Bay Campus in an awardwinning building Gladstone offers competitive salaries and benefits providing an optimal environment for individuals to realize their full potential and make a meaningful impact on global health
About the Role
The GladstoneUCSF Institute of Virology is seeking a highly motivated Research Associate (RA) to lead a groundbreaking project focused on massively parallel functional genomics and highthroughput screening of bacteriophage genes. This position offers the unique opportunity to work directly with Principal Investigator (Sukrit Silas) in advancing the labs core missiondeploying an innovative screening platform across diverse bacterial species. The RA will take a leadership role in constructing complex libraries of tens of thousands of phage genes and conducting functional genomics experiments that measure genetic interactions between phages and bacteria on an unprecedented scale.
Our institute is at the forefront of applying systems biology approaches to fundamental questions in phage biology. Through these novel technical capabilities we are systematically mapping the antiviral immune architecture of bacteria to identify critical defensive barriers. This knowledge will drive the development of rationally engineered phage therapies to combat the escalating threat of antibioticresistant pathogens. Potential research projects will explore applications in:
Neutralizing ESKAPE pathogens
Developing phage therapeutics for antibioticresistant UTIs
Reducing mortality in cholera epidemics
Engineering phages to modify the oral microbiome
What you will do:
The RA will collaborate closely with the PI (Sukrit Silas) and contribute to highimpact research with the potential to publish one or more papers within a twoyear period. This role is particularly wellsuited for individuals considering graduate medical or dental school. This position requires exceptional organizational skills and personal initiative.
Your primary role will be developing and optimizing phagehost screening protocols using a broad range of molecular biology techniques such as:
Restriction enzyme cloning Gibson Assembly Gateway cloning
Gel electrophoresis PCR bacterial transformation
DNA/RNA purification and NGS sample preparation
Leading and meticulously documenting complex projects using Benchling
Assisting with research planning including primer and vector design experimental analysis troubleshooting and data interpretation
Maintaining detailed experimental records and presenting findings at regular team meetings
Managing general laboratory operations including reagent procurement inventory organization and compliance with safety regulations
What you will need:
Bachelors degree (BA/BS) in Cell and Molecular Biology or a related field is preferred with a minimum of one year of handson research laboratory experience. Candidates with an Associates degree and at least two years of relevant experience will also be considered.
Strong ability to work independently demonstrating initiative and problemsolving skills
Exceptional attention to detail with excellent organizational verbal and written communication skills
Proactive approach to learning new techniques and optimizing protocols
Effective time management skills with the ability to prioritize tasks collaborate with team members and meet multiple deadlines
Commitment to following established policies and procedures
Availability for evening and weekend hours as required; this is a fulltime inperson position based in Mission Bay San Francisco
What we prefer:
Experience in bacterial cell culture maintenance and transformation
Proficiency in molecular biology techniques including:
PCR DNA extraction and purification ligation
DNA construct design and cloning
DNA library construction and sequencing (Sanger NGS)
Protein expression and analysis techniques (e.g. Western Blotting
Previous experience with laboratory management and inventory control
What is nice to have:
Experience with RNA and bacteriophage handling
Proficiency in Microsoft Office Suite (Word Excel)
This position offers an exciting opportunity to contribute to cuttingedge research in phage biology and antibiotic resistance while gaining invaluable laboratory experience in a dynamic and collaborative environment.
**** Role opens in June / July 2025 *****
Hiring Range:
$27hr $31.11hr
Gladstone Perks & Benefits
Peoplework with talented committed and supportive teammates within an organization that values each member of its community.
A meaningful place to grow and learnwhether its your professional skills or scientific knowledge we have the resources and environment to advance either so you can better support Gladstones mission to drive a new era of discovery in diseaseoriented science and to mentor tomorrows leaders in an inspiring and diverse environment.
Healthy work/life balanceyou are highly engaged and productive at work because you can have time to recharge and enjoy a vibrant life outside of work.
Compensationcompetitive salary. Title and salary will be commensurate with education and experience.
Excellent benefitsgenerous medical dental vision retirement plan paid vacation commuter benefits access to free shuttle transportation.
Gladstone is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race color sex religion national origin ancestry age marital status medical condition physical or mental disability veteran status sexual orientation or any other nonjob related characteristic. We make all employment decisions so as to further this principle of equal employment.
Required Experience:
IC
Employment Type
Full-Time
