Senior Scientist Bioinformatics and Data Scientist for Biocatalysis
Senior Scientist Bioinformatics and Data Scientist for Biocatalysis
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Job Description
Senior Scientist Bioinformatics and Data Scientist for Biocatalysis
Location:Cambridge UK
About AstraZeneca
AstraZeneca is a global scienceled patientfocused biopharmaceutical company that focuses on the discovery development and commercialisation of prescription medicines for some of the worlds most serious diseases. But were more than one of the worlds leading pharmaceutical companies. At AstraZeneca we are pioneering new frontiers by identifying and treating patients earlier working towards the aim of eliminating cancer as a cause of death.
One of our core departments Early Chemical Development (ECD) specialises in earlyphase Drug Substance Manufacturing taking projects from discovery chemistry through to Phase II clinical trials. Our team skills spans process chemistry analytical chemistry crystallization process design route design biocatalysis and much more.
Come and join our AZ team where you will play a pivotal role in this exciting period of development!
We are seeking a passionate Senior Scientist Bioinformatics and Data Scientist for biocatalysis to join the Biocatalysis Enzyme Discovery and Engineering Team within ECD at the DISC. In this role you will provide support for enzyme discovery and engineering activities for early but also late portfolio projects increasing capabilities for the team. Using your expertise in bioinformatics you will support the design and optimisation of enzymes to establish efficient sustainable biocatalytic processes.
This role is based at AstraZenecas Cambridge DISC R&D Hub and involves advanced computational work using tools software and platforms to contribute to groundbreaking enzyme design and drive innovation. You will collaborate with internal and external partners in a highly multidisciplinary environment to deliver timely biocatalytic solutions. AstraZeneca also provides access to internal AIdriven chemistry and protein science specialists ensuring a dynamic and highly multidisciplinary environment.
Key Responsibilities:
Leading bioinformatics and molecular modelling activities for enzyme design and engineering.
Supporting enzyme variant data management across projects and driving our Biocatalysis management data strategy.
Working collaboratively to link and codevelop database and dashboard solution for computational results used in drug project development.
Designing diverse enzyme panels using genome/database mining and advanced bioinformatics approaches
Develop and maintain data analysis pipelines and data management for high throughput screening and sequencing data
Providing multifunctional bioinformatics expertise to biocatalysis teams companywide from discovery to commercial manufacturing.
Collaborating with internal and external partners to ensure innovative technologies in enzyme design.
Integrating biocatalytic routes into chemical retrosynthetic software.
Facilitating tech transfer to external CMOs/CROs for biocatalytic step development and manufacturing campaigns.
Driving innovation through participation in crossfunctional networks and integrating biocatalytic methods into workflow improvements.
Staying ahead of advancements within biocatalysis and bioinformatics sharing insights within the team.
Adhering to Safety Health & Environment (SHE) compliance and quality standards in all aspects of the role.
Requirements:
Bachelors degree (or equivalent) in biocatalysis bioinformatics molecular modelling computational chemistry or data sciences with extensive experience in the field.
Strong expertise in protein structure analysis design and simulation tools including:
Structure prediction
Molecular dynamics simulations
Docking
In silico protein design
Expertise in protein sequence analysis and evolution and well as the use of Schrodinger Rosetta AlphaFold
Strong programming skills (e.g. Python)
Familiarity with statistical analysis and modern data science tools.
Experience in data science and data management
Experience in Machine Learning applied to protein design
Ability to work on linuxbased HPC systems
Excellent written and oral communication skills
Collaborative teamfocused approach with conform in interacting with highly multidisciplinary and diverse teams.
Desirables:
PhD (or equivalent) in computational structural biology such as Computational Chemistry Molecular Modelling Biophysics.
Postdoctoral or industrial experience in relevant subject areas.
Experience in enzyme panel design
Solid understanding of biochemistry biocatalysis molecular biology and directed evolution
Experience in analysing big set of data including NGS sequence processing.
Experience in database creation and management (e.g. SQL)
Previous experience collaborating with molecular biologists microbiologists biochemists and organic chemists.
Understanding of patent and IP strategies.
In Office Requirement:
When we put unexpected teams in the same room we unleash bold thinking with the power to inspire lifechanging medicines. Inperson working gives us the platform we need to connect work at pace and challenge perceptions. Thats why we work on average a minimum of three days per week from the office. But that doesnt mean were not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.
Why AstraZeneca
Join the team unlocking the power of what science can do. We are working towards treating preventing modifying and even curing some of the worlds most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. Its our combination of curiosity and courage that drives us inspired by the possibility of doing things that have never been done before. Empowered to step up we free ourselves from fear of failure to dig deep into the biology of complex diseases and make bold decisions. Celebrating our successes and failures along the way.
Competitive salary and benefits package on offer.
The successful candidate will have access to a flexible employee benefits fund including holiday purchase and flexible time off pension contributions Share Save Plans A performance recognition scheme and a competitive generous remuneration package.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process to perform essential job functions and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Date Posted
10Mar2025Closing Date
23Mar2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Required Experience:
Senior IC
Employment Type
Full-Time
