In this role you will be responsible for leading the process development of cultivated fish cell culture scale-up from static and small-scale dynamic culture to 50 L. This will require experimental design wet-lab work and data analysis for cell proliferation at increasing scale. Successful candidates will be expected to drive upstream process development activities develop and clearly communicate requirements to inputs teams and will bring expertise in operating scale-down bioreactors developing optimized bioprocesses and scaling process from bench to pilot.
Responsibilities
Design and set up a bioreactor lab including coordinating with vendors to qualify and procure bioreactors and supporting equipment
Perform experimental screening of bioprocess approaches at bench-scale to establish optimal processes and operating modes in line with future commercialization targets
Develop robust iterative scale-down processes to maximize yield and process efficiency at benchtop (<10L) scale
Mentor the Junior bioprocess scientist in process parameter optimization during scale up from shake flask to small scale reactors
Define key process parameters for scale-up and develop analytical methods for continuous process monitoring and control
Align with senior leadership to implement critical decisions
Lead co-development partnerships to drive shared process development goals
Conduct rigorous experimental design documentation and data analysis
Provide concise and effective reporting on project deliverables and presentation of data
Evaluate processes and assumptions for potential improvements to efficiency and manufacturability providing creative solutions to challenging technical problems
Requirements
Experience
M.S. or PhD in a relevant field (Bioengineering Chemical Engineering Cell Biology or equivalent
5 years of industry experience (MS) or 3 years of industry experience (PhD) in biotechnology cell manufacturing or a relevant engineering field
2 years of direct experience in lab to mid-scale (50-500L) animal cell culture in a process development environment
Experience with batch and fed-batch cell culture is essential; intensified or continuous process experience is a plus
Tech transfer experience is preferred
Experience with scale-down model development predictive modeling and model validation is a plus
Experience with high throughput bioreactor systems and automation is a plus
Track record of successfully leading small teams is strongly preferred
Strong track record of peer-reviewed publications is preferred
Demonstrated scientific rigor toward continuous improvement
Desired technical skills
Proficiency with Design of Experiments (DOE) methodology for bioprocess development including experiment design and data analysis
Proficiency in engineering techniques including quantitative modeling and mass balance
Familiarity with mammalian metabolic pathways and proficiency in metabolic flux analysis is a plus
Understanding of a range of analytical chemistry techniques necessary to support process development
Ability to work in a fast-paced dynamic environment and skills to prioritize and deliver against timelines
Strong troubleshooting and problem-solving skills
Excellent written and verbal communication skills including strong command of the English language
Required Skills:
We are skeeing a Bioprocess Lead Scientist who will be responsible for leading the process development of cultivated fish cell culture scale-up from static and small-scale dynamic culture to 50 L. This will require experimental design wet-lab work and data analysis for cell proliferation at increasing scale. Successful candidates will be expected to drive upstream process development activities develop and clearly communicate requirements to inputs teams and will bring expertise in operating scale-down bioreactors developing optimized bioprocesses and scaling process from bench to pilot.
Required Education:
The successful candidate must have:M.S. or PhD in a relevant field (Bioengineering Chemical Engineering Cell Biology or equivalent5 years of industry experience (MS) or 3 years of industry experience (PhD) in biotechnology cell manufacturing or a relevant engineering field2 years of direct experience in lab to mid-scale (50-500L) animal cell culture in a process development environment
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Experience Required:
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