Biochemistry Research Associate Enzymology (Gene-to-Assay) CDI- MF

We are Pierre Fabre Laboratories a global leader combining pharmaceutical expertise with dermo-cosmetics to support consumers and patients at every stage of their care journey.
Our portfolio includes several medical franchises and international brands such as Eau Thermale Avène Ducray A-Derma Klorane René Furterer and Pierre Fabre Oral Care.
By joining us you become part of a meaningful company where the human dimension is essential. You become a participant in the We Care Movement a movement that values excellence and innovation within passionate teams. Together we push the boundaries of science to unite health and beauty for the benefit of all because Every time we care for a single person we make the whole world better.

Present in 120 countries with a team of over 10000 employees we are proud to create a scientific and human impact today and tomorrow! If caring is at the heart of your values join Pierre Fabre Laboratories and become a key player in the We Care Movement.

We are seeking a talented and highly motivated Biochemistry Research Associate to join our Oncology Drug Discovery team and support our small molecule/antibody identification and characterization efforts.

The ideal candidate will have relevant experience in the pharmaceutical / biotech industry with sound hands-on expertise in designing executing and interpreting biochemistry experiments using state-of-the-art bioinformatics molecular biology protein expression/purification enzymatic activity- and binding assay development techniques.

This position is a lab-based and attached to our Oncopôle site in Toulouse France.

Your role within a pioneering company in full expansion:

Key Responsibilities

• Design protein constructs for functional/structural characterization purposes.
• Generate vectors for heterologous recombinant protein expression in bacteria insect- and/or mammalian cell hosts.
• Develop and optimize methods for protein extraction purification characterization and quantification with a high level of independent critical thinking.
• Characterize protein activity and biomolecular interactions in support to target discovery and validation efforts by the target discovery and enablement teams.
• Ensure high-quality data generation analysis and timely report to project teams.
• Leverage lab automation to improve assay operation quality and overall productivity.
• Properly document experimental design findings and protocols and comply with all laboratory training and safety requirements.
• Collaborate with multi-disciplinary project teams and communicate scientific/technical contributions to deliver on project goals in relevant meetings.
• Establish relationships and coordinate collaborations with vendors external partners and CROs to achieve high standards of productivity and quality extend internal capabilities and optimally serve project needs.
• Drive scientific and technical innovations to develop and enhance functional capabilities.

We offer an attractive remuneration/benefits package: Incentives profit-sharing Pierre Fabre shareholding with matching contribution health and provident insurance 16 days of holidays (RTT) in addition to 25 days of personal holidays public transport participation very attractive CE...

Your skills at the service of innovative projects:

• MSc in Biochemistry Biophysics or related field with 5 years experience in abiotech/pharmaceutical setting (or recent Ph.D. with relevant exposure to drug discovery).
• Demonstrated hands-on proficiency with heterologous protein expression systems and protein extraction and purification methods (e.g. chemical and mechanical cell lysis ultracentrifugation dialysis batch- and column liquid chromatography).
• Command of several techniques for the characterization of enzyme activities protein-protein and protein-ligand interactions (e.g. UV/VIS and fluorescence spectroscopy mass spectrometry surface plasmon resonance isothermal calorimetry microscale thermophoresis chemical and thermal unfolding/denaturation assays analytical ultracentrifugation circular dichroism interferometry static- and dynamic light scattering).
• Expertise with mechanistic enzymology and/or molecular pharmacology are highly desired.
• Working knowledge of adjacent disciplines for protein structure characterization is a plus.
• Proficiency with relevant data processing analysis and visualization software tools.
• Experience in oncology is a plus.
• Motivated and agile team player with the ability to work in a collaborative environment across the R&D organization.
• Excellent verbal and written communication skills in English are essential.

At Pierre Fabre Laboratories we believe that our greatest asset is our people.

We are committed to a policy of Equal Employment Opportunity and will not discriminate against an applicant or employee based on race color religion creed national origin or ancestry sex sexual orientation gender identity or expression age physical or mental disability veteran or military status genetic information or any other legally recognized protected basis under federal state or local law. The information collected by this application is solely to determine suitability for employment verify identify and maintain employment statistics on applicants. Applicants with disabilities may be entitled to reasonable accommodation under the Americans with Disabilities Act and certain state or local laws. Please inform the companys personnel representative if you need assistance completing this application or to otherwise participate in the application process. Thus we commit to considering all applications equally without fail.