Senior Scientist Target Discovery & Validation – Induced Proximity Platform (IPP)

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Job Description

Join Amgens Mission of Serving Patients

At Amgen if you feel like youre part of something bigger its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980 weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology Inflammation General Medicine and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer heart disease inflammatory conditions rare diseases and obesity and obesity-related conditions. As a member of the Amgen team youll help make a lasting impact on the lives of patients as we research manufacture and deliver innovative medicines to help people live longer fuller happier lives.

Our award-winning culture is collaborative innovative and science based. If you have a passion for challenges and the opportunities that lay within them youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Role: Senior Scientist - Target Discovery & Validation Induced Proximity Platform (IPP)

Reports to: Principal Scientist

Location: Burnaby BC

What You Will Do

Lets do this. Lets change the world. Amgen is seeking a passionate and innovative Scientist to join the Induced Proximity Platform team in Burnaby. This role is at the frontier of discovery biology combining induced proximity technologies to uncover novel therapeutic targets across Amgens key therapeutic areas including Oncology Inflammation and Cardiometabolic diseases

The successful candidate will lead and support cell surface target discovery validation and functionalization efforts by developing and applying innovative in vitro assays proteomics workflows and flow cytometry based approaches. This role will contribute to large molecule multispecific therapeutic development through target validation model development and MOA studies while collaborating across multidisciplinary teams to analyze data communicate findings and maintain high-quality experimental documentation

• Design implement and execute complex experimental workflows to profile and validate cell surface proteins.
• Lead and support cell surface-based target discovery and validation projects using in vitro models (cell lines primary cells tissues etc.).
• Apply proximity labeling cell surface enrichment and related proteomics efforts for target validation and nomination studies.
• Support target functionalization efforts toward developing multispecific antibody therapeutics and perform efficacy mechanism of action (MoA) and drug response studies for these therapeutics.
• Use cutting-edge software tools and collaborate with bioinformatics to analyze and interpret target discovery proteomics datasets.
• Collaborate across multidisciplinary teams to drive integrated target discovery validation and functionalization efforts.
• Present findings internally and externally through team meetings conferences and peer-reviewed publications.
• Maintain detailed electronic lab notebooks and experimental records.

What We Expect of You

We are all different yet we all use our unique contributions to serve patients. The qualified professional we seek is a Scientist with these qualifications.

Basic Qualifications:

• Doctorate degree and 3 years of relevant scientific experience
• Masters degree and 6 years of relevant scientific experience

Preferred Qualifications:

• Expertise in proximity labeling proteomics platforms and target validation using flow cytometry biochemical and imaging-based techniques.
• Experience in cell line generation and overexpression systems (e.g. lentiviral delivery).
• Experience with antibody therapeutics and functional validation of targets using cell-based assays.
• Hands on experience with cloning expression and purification analysis is a plus.
• Familiarity with high-throughput automation platforms (e.g. Agilent Bravo) high-content imaging platforms and analysis software.
• Track record of scientific innovation publications and/or conference presentations.
• Demonstrated ability to work collaboratively in fast-paced multidisciplinary teams.
• Excellent verbal written and organizational skills.

What you can expect of us

As we work to develop treatments that take care of others we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture well support your journey every step of the way.

Amgen is proud to have been recognized as one of LinkedIn Top 25 Companies in Canada for career growth. Click HERE for more details. If you have a passion for challenges and the opportunities that lay within them youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

The salary range for this position is $115503 - $156269.

In addition to base salary Amgen offers competitive and comprehensive total compensation programs aligned with local industry standards.

Apply now for a career that defies imagination

Objects in your future are closer than they appear. Join us.

As an organization dedicated to improving the quality of life for people around the world Amgen fosters an inclusive environment of diverse ethical committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race color religion sex sexual orientation gender identity national origin protected veteran status disability status or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process to perform essential job functions and to receive other benefits and privileges of employment. Please contact us to request accommodation.

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