SeniorPrincipal Scientist Biotransformations

At Johnson & Johnsonwe believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented treated and curedwhere treatments are smarter and less invasive andsolutions are our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for more at .

As guided by Our Credo Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson we respect the diversity and dignity of our employees and recognize their merit.

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Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

Learn more at & Johnson Innovative Medicine (J&J IM) develops treatments that improve the health of people worldwide. Research and development areas encompass cardiopulmonology immunology communicable diseases neuroscience and oncology. Our goal is to help people live longer healthier lives. We have produced and marketed many first-in-class prescription medications and are poised to serve the broad needs of the healthcare market from patients to practitioners and from clinics to hospitals. To learn more about J&J Innovative Medicine visit https:// Translational ADME Biotransformation team in Beerse Belgium is looking for a highly motivated Senior or Principal Scientist to support drug discovery and development programs. The team is part of the department of Translational Pharmacokinetics/Pharmacodynamics and Investigative Toxicology (TPPIT) and plays a pivotal role in support of drug metabolism related studies for small and large molecule drug discovery and development programs as well as in developing and applying advanced analytical chemistry solutions to solve mechanistic questions.

We are a highly motivated team and our laboratories are state-of-the-art. As part of the globalTranslational ADME community within TPPIT you will have access to a large arsenal of in silico in vitro in vivo and analytical tools and the vast expertise of colleagues at our various research sites in Belgium and the United States.

Key Responsibilities

• To manage and coordinate metabolite profiling and identification studies for a broad range of modalities (small molecules degraders peptides oligonucleotides etc.) including design plan and conduct of in vitro incubations perform high quality analysis and write high quality scientific reports
• To perform liquid chromatography analysis with MS UV and radioactive detection including method development and data analysis and interpretation
• Serve as a subject matter expert for biotransformations putting data into broader context and suggest and develop follow-up in vitro or in vivo experiments
• Effectively communicate data and their relevance to multidisciplinary project teams management and potential partners through internal and external presentations and publications
• To keep abreast with the current advances in MS automation and related technologies and apply new technologies and methods to increase sensitivity quality and throughput

Qualifications

• PhD in Medicinal/Organic Chemistry Pharmaceutical Sciences Biochemistry Pharmacokinetics Drug Metabolism or related field or multiple years of relevant experience in the field of biotransformations
• Hands-on experience in structure elucidation using mass spectrometry
• In depth knowledge of biotransformation reactions and enzymes involved
• Hands-on experience with non-small modalities (oligonucleotides peptides and proteins) is an asset
• Experience with bioinformatics applications is an asset
• Experience in maintenance of chromatography and mass spectrometry instrumentation and developing and troubleshooting LC/RAD and LC/high-resolution MS assays
• Ability to independently diagnose and solve complex technical and scientific problems
• Team player with strong interpersonal skills in an international team setting including a matrix environment
• Proven track record of scientific achievement & project influence through publications and other interactions
• The working language is English

Seniority level is currently open and will be selected based on experience.

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Benefits:

In addition to base pay we offer the following benefits*: an annual bonus with set target (% of pay) depending on pay grade / location where the actual amount is based on the employees and companies performance of the previous calendar year or sales commissions. Moreover we offer vacation days parental leave for a minimum of 12 weeks bereavement leave caregiver leave volunteer leave well-being reimbursement programs for financial physical and mental health. We also offer service anniversary and recognition awards and subject to the terms of their respective plans employees - and in some locations eligible dependents - can participate in several insurance plans. For more information visit Employee benefits Supporting well-being & career growth Johnson & Johnson Careers.

*This is for informative purposes only. Amounts and actual benefits may vary by location and are subject to change.