Senior Principal Scientist – Dissolution and In Vitro Release Sciences, Simulations, and Optimization (DISSO)

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Dissolution and In Vitro Release Sciences Simulations and Optimization (DISSO) is a global team within Analytical Development (AD) part of Synthetics Development (SD). Together we develop validate and transfer dissolution and in vitro release (IVR) methods for immediate modified and targeted release formulations across oral parenteral long-acting and other administration routes characterizing modeling and predicting release in standard and biorelevant media and shaping clinically relevant control strategies across the lifecycle.

Three pillars anchor our work:

• Method and Control Strategy Development the best QC method and control strategy at launch and beyond.
• Drug Substance / Drug Product and Process Development Support the best drug product and process at launch and across the lifecycle.
• Talent Development growing the next generation of leaders in DISSO AD and Synthetics Development.

Based at the Beerse Campus Belgium.

Job Title: Senior Principal Scientist Dissolution and In Vitro Release Sciences Simulations and Optimization (DISSO)

Ready to define the future of dissolution and in vitro release at J&J Join DISSO as a Senior Principal Scientist a leading expert who sets scientific strategy at portfolio and project level sparks innovation in dissolution development automation and modeling and grows the next wave of dissolution scientists. Influence the field externally through Health Authority working groups scientific conferences and consortia.

The Successful Candidate

Scientific Leadership & Strategy

How would you move a global dissolution portfolio forward Define the strategy spanning dissolution IVR biopharmaceutics and clinically relevant controls. Steer multiple complex programs alongside the DISSO Leadership Team and partners safeguarding scientific integrity and data quality across every deliverable.

Innovation Technical Excellence & Process Robustness

What does technical excellence look like in modern dissolution science Craft robust methods and control strategies that enable smooth execution and thoughtful risk-taking. Accelerate scale-up from early development through commercial transfer design studies that guide formulation and process choices (biorelevant and biopredictive dissolution mechanistic modeling PBBM IVIVC/IVIVR) and bring in automation AI-enabled workflows and digital ways of working together with partners across Drug Product Development Process Development CMC RA Clinical Manufacturing MSAT and Quality.

Regulatory & External Scientific Influence

Want to influence how dissolution science is practiced and regulated globally Translate science into regulatory impact through dissolution and biopharmaceutics sections of IND/IMPD NDA/MAA and lifecycle filings and engage directly with Health Authorities (FDA EMA PMDA and others). Shape the external community through HA working groups (e.g. ICH FDA EMA) industry consortia conference talks and peer-reviewed publications then bring fresh insights back into DISSO.

Mentorship Coaching & Communication

Energized by growing people and ideas Mentor and coach scientists support matrix teams across DISSO projects and bring decision-ready scientific narratives to senior management and governance bodies. Embody J&Js Credo and Leadership Imperatives in everyday decisions.

Qualifications

Education & Experience

PhD in Pharmaceutical Sciences Biopharmaceutical Sciences Analytical Chemistry Chemical Engineering or a related field or equivalent advanced experience. 10 years in dissolution sciences biopharmaceutics formulation or analytical development at a major pharmaceutical company with a clear track record across the full product lifecycle early and late-stage development regulatory submission and commercial lifecycle management and impact at portfolio level.

Hands-on experience expected in several of:

• Local delivery and long-acting injectable formulations
• Amorphous solid dispersions
• Dissolution modeling (mechanistic and/or PBBM) and IVIVC/IVIVR
• Biopredictive and clinically relevant dissolution methods
• Dissolution automation and digital workflows

Competencies & Knowledge

Ready to bring deep regulatory knowledge into action Solid command of Health Authority regulations and guidance on dissolution specifications formulation/process bridging IVIVC/IVIVR and biopharmaceutics plus comfort engaging the external scientific and regulatory community. A strong mentor and matrix leader who connects teams without relying on formal hierarchy. Navigates GMP environments with ease and crafts high-quality scientific documentation. Curious problem-solver open to new perspectives willing to challenge the status quo with care. Digital mindset at ease with data analysis modeling automation and AI-enabled tools with attention to data integrity and lineage. Fluent written and spoken English; knowledge of Dutch is a plus or willingness to learn the basics. Works in line with EH&S rules GMP and J&J quality standards.

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In addition to base pay we offer the following benefits*: an annual bonus with set target (% of pay) depending on pay grade / location where the actual amount is based on the employees and companies performance of the previous calendar year or sales commissions. Moreover we offer vacation days parental leave for a minimum of 12 weeks bereavement leave caregiver leave volunteer leave well-being reimbursement programs for financial physical and mental health. We also offer service anniversary and recognition awards and subject to the terms of their respective plans employees - and in some locations eligible dependents - can participate in several insurance plans. For more information visit Employee benefits Supporting well-being & career growth Johnson & Johnson Careers.

*This is for informative purposes only. Amounts and actual benefits may vary by location and are subject to change.