Scientist Biopharmaceutics (in vitroin silico)

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Ourexpertisein Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you workinteams that save lives by developing the medicines of tomorrow.

Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

Learn more at are seeking aBiopharmaceutics In Vitro/In Silico Scientistbased in Beerse Belgium.

Purpose:

Johnson & Johnson Innovative Medicinedevelopsinnovative effective treatments across four therapeutic areas with high unmet medical need: oncology immunology neuroscience and cardiopulmonary diseases. The Janssen campus in Beerse near Antwerp Belgium offers a unique ecosystem spanning the full drug development life cycle with capabilities ranging from basic science to market access on a single campus.

The biopharmaceutics group is part of Pharmaceutical & Material Sciences in Pharmaceutical Product Development &Supply andcooperates closely with the High Throughput andPreformulationSciences (HTPS) group to perform all in vitro work. Both groups support the drug product design process for synthetic molecules(includingoralpeptides)by characterizing andoptimizingthe relationship between active ingredient properties drug product performance and in vivo behavior.

You willbe responsible for:

• The design and executionofin vitro experiments including standard and customized solubility precipitation and dissolution testing to support biopharmaceutical profiling for development projects in the synthetic molecule portfolio with a focus on oral peptides.

• ingin silico absorption modeling such asphysiology basedbiopharmaceutics and/or pharmacokinetic modeling to characterize the interface between drug product performance and physiological conditionsand to predict absorption and permeation(incloral peptides).

• Workingat the interface between Biopharmaceutics and High ThroughputPreformulationSciences and integrateallin vitro and in silico datatoassess predictand improvethe absorptionof oral synthetic molecules including peptides

• Collaboratingproactively with external partners including academic institutions and private research organizations to stay current with emerging scientific industrial and regulatory developments in biopharmaceutics across in vitro and in silico approaches.

• Todrive innovation ofintegratedin vitro/in silicoworkflows toacceleratebiopharmaceuticalunderstandingandrational formulationdesign/selectionBuildingstrong partnerships with key stakeholders including Discovery Sciences Preclinical DMPK Non-Clinical Safety Clinical Pharmacology Regulatory Affairs API Development Drug Product Development and Analytical Development.

Qualifications/Requirements:

• Masters or Doctoral degree (Ph.D.) in Pharmaceutical Sciences Chemistry Biology Engineering or a related scientific field withpreferablymore than two years of relevant industrial experience in biopharmaceuticsincludingpreformulationaspectsand computational modeling preferably in drug absorption and disposition.

• Knowledge of some of the following areas is preferred:physico-chemicalcharacterisation drug absorption and disposition formulation development and design for oral peptides and pharmacokinetics.

• Proven ability to contribute as an independent scientific specialist with excellent interpersonal communication and collaboration skills anda strong senseof personal accountability.

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