Principal Scientist Pharmacology

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Position Title:

Principal Scientist Pharmacology.

3Rs Portfolio Innovation and External Engagement.

Location:

Beerse Antwerp Belgium

Role Summary

The Principal Scientist NAMs Innovation is a scientific role within Scientific & In Vivo Strategies (SIS) responsible for executing/coordinating internal and external NAMs development/evaluation opportunities.

Working under the scientific direction of the Sr. Principal Scientist & SIS Scientific Lead this role applies strong technical expertise in ex vivo in vitro and in chemico NAMs approaches that will enable identified NAM opportunities and support their appropriate development evaluation and implementation to enable the portfolio through a combination of both internal lab-based and externally managed efforts.

Operating within the enterprise 3Rs framework and aligned with Discovery Product Development & Supply (DPDS) Preclinical Safety & Translational Sciences (PSTS) and SIS strategic priorities the Principal Scientist plays a key role in translating NAM strategy into programrelevant scientific insights enabling strengthening of preclinical assessments and in silico approaches improved clinical translational relevance and enhanced alignment with 3Rs.

Primary Responsibilities:

Supporting Internal and External NAMs Development/Evaluation Efforts:

• Execute scientific evaluation of ex vivo in vitro and in chemico NAM opportunities relevant to discovery and development programs

• Support assessment of applicability strengths limitations and readiness of NAMs within defined disease modality and contextofuse scenarios

• Partner with SIS Scientific Leads and TA/PSTS stakeholders to support evaluation and incorporation of NAMs into program and functional area strategies under guidance of the Sr. Principal Scientist

• Enable in silico approaches through collaboration to understand and deliver on key outputs from ex vivo in vitro and in chemico models to drive/improve upon in silico model development

External NAMs Landscape Monitoring:

• Track developments in the external NAMs landscape including academic advances emerging platforms and biotech technologies

• Compile and synthesize information on scientific maturity translational relevance and regulatory context of external NAM approaches

• Provide structured summaries and analyses to support portfoliolevel discussions and prioritization

Internal Capability Execution:

• Support assessments of internal NAM capabilities and gaps relative to program needs and regulatory expectations

• Contribute to lab-based NAM development evaluation and validation activities including documentation of learnings and outcomes

• Assist in development of internal tools guidance or exemplars that enable awareness and consistent application of NAMs across the enterprise

Scientific Collaboration & Communication:

• Act as a daytoday scientific partner for TA and discovery area scientists seeking guidance on or collaboratively developing NAMenabled approaches

• Contribute to internal scientific reviews working groups and forums related to NAMs and translational innovation

• Support preparation of internal and external scientific materials including communications presentations and publications related to NAM implementation

Domestic and international travel may be required; up to 10%.

May perform other duties and matrix manage team members as assigned.

Education-Minimum Qualification

• Ph.D. in bioengineering biomedical engineering pharmacology toxicology systems biology or a related discipline with a concentration in neuroscience immunology and/or oncology.

• 2-5 years of postdoctoral experience in academic pharma biotech or a related research setting focused on NAMs-related platform development (i.e. CIVM/MPS etc.)

Required Skills

• Demonstrated hands-on expertise with NAMs including ex vivo complex in vitro (CIVM/MPS/organoids) and/or in chemico approaches and experience working cross-functionally with data scientist colleagues to leverage such platforms to enable in silico modeling efforts

• Ability to critically evaluate emerging technologies and communicate findings clearly to cross-functional teams

• Strong collaboration skills in a matrixed scientific environment

• Experience synthesizing scientific and technical information for portfolio or governance discussions

• Expertise in basic pharmacology concepts (EC50 Emax etc.) and experience in relevant data analysis best practices and software/tools

• Demonstrated contributions to scientific publications internal reports or technical presentations

• Experience interacting with external technology developers or academic collaborators

Preferred Skills

• Familiarity with regulatory science considerations relevant to NAM adoption

• Experience supporting NAM evaluation or development efforts within a pharma or biotech R&D discovery/preclinical organization

Required Skills:

Preferred Skills:

The anticipated base pay range for this position is:

Benefits:

In addition to base pay we offer the following benefits*: an annual bonus with set target (% of pay) depending on pay grade / location where the actual amount is based on the employees and companies performance of the previous calendar year or sales commissions. Moreover we offer vacation days parental leave for a minimum of 12 weeks bereavement leave caregiver leave volunteer leave well-being reimbursement programs for financial physical and mental health. We also offer service anniversary and recognition awards and subject to the terms of their respective plans employees - and in some locations eligible dependents - can participate in several insurance plans. For more information visit Employee benefits Supporting well-being & career growth Johnson & Johnson Careers.

*This is for informative purposes only. Amounts and actual benefits may vary by location and are subject to change.

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