Postdoctoral Scholar, AIML for drug metabolite prediction and LC-MS analytical chemistry

At Johnson & Johnsonwe believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented treated and curedwhere treatments are smarter and less invasive andsolutions are our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for more at .

As guided by Our Credo Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Job Sub Function:

Job Category:

All Job Posting Locations:

Job Description:

The Drug Discovery Data Science team in Beerse Belgium and Spring House Pennsylvania USA is seeking a highly motivated postdoctoral scholar for a two-year contract to develop an AI/ML-driven platform for predicting drug metabolites (SOM) pharmacokinetics and molecular properties facilitating LC-MS-based structure elucidation and compound this role the candidate will conduct fundamental research making use of extensive internal biochemical and analytical datasets. This will result in meaningful and transformative impacts on ongoing drug discovery and development projects by applying the tools developed. Given the multidisciplinary nature of the project the candidate will collaborate with a diverse group of drug discovery and development experts along with data scientists while developing explainable AI tools with aspects of uncertainty estimation and active learning approaches while leveraging a cutting-edge molecular AI architecture.

A successful candidate should demonstrate a strong capacity to build evaluate and benchmark deep learning methods and communicate findings in peer reviewed publications. Additionally they should be an effective communicator and be comfortable leveraging a large internal network for the purpose of data curation and generation.

Drug Discovery Data Science team is a part of Therapeutics Discovery and brings innovative AI/ML solutions to all steps and areas of drug discovery process enabling long-term visionary plans within the company surrounding the new discovery paradigm.

Tasks/Duties/Responsibilities

• Design development and evaluation of models for analytical instrumentation metabolite prediction and PK/PD

• Leveraging public data and our internal network for the creation and curation of relevant data

• Deployment and application of models in an industrial setting

• Writing peer reviewed publications

• Development training conferences internal meetings and symposia

Required Minimum Education: PhD degree in Computational chemistry Cheminformatics Physical Chemistry Analytical Chemistry Machine Learning Data Science or a related field

Required Years of Related Experience:0-4

Required Knowledge Skills and Abilities:

• Strong background and practical experience in applying machine learning and deep learning methods benchmarking AI models
• Strong background in conventional cheminformatics respective python packages and software
• General understanding of general organic and analytical chemistry
• Strong scientific publication track record (peer reviewed publications patents preprints) and/or demonstrated contributions to computer codebases
• Proficiency in Python to the capacity to quickly prepare analyze and build models around data
• Highly collaborative and capable of working with a large internal network to leverage various data sources

Keywords: Python Machine Learning Deep Learning Data Science General Chemistry

Preferred Area of Study: AI/ML for Chemistry

Preferred Knowledge Skills and Abilities:

• Strong understanding of analytical chemistry and chemical instrumentation

• Understanding of drug metabolization and PK/PD

• Modeling experience utilizing uncertainty-aware learning conformal learning and active learning

• Application and understanding of modern agentic workflows and LLMs

• Practical understanding of liquid chromatography and mass spectrometry

• Knowledge of modern databases

• Experience with automation and robotization of scientific instruments

Keywords: Analytical Chemistry Chromatography Mass Spectrometry PK/PD & Metabolism Agentic Workflows Uncertainty-Aware Learning Conformal Learning Active Learning

Required Skills:

Preferred Skills:

The anticipated base pay range for this position is:

Benefits:

In addition to base pay we offer the following benefits*: an annual bonus with set target (% of pay) depending on pay grade / location where the actual amount is based on the employees and companies performance of the previous calendar year or sales commissions. Moreover we offer vacation days parental leave for a minimum of 12 weeks bereavement leave caregiver leave volunteer leave well-being reimbursement programs for financial physical and mental health. We also offer service anniversary and recognition awards and subject to the terms of their respective plans employees - and in some locations eligible dependents - can participate in several insurance plans. For more information visit Employee benefits Supporting well-being & career growth Johnson & Johnson Careers.

*This is for informative purposes only. Amounts and actual benefits may vary by location and are subject to change.