Senior Scientist Safety Assessment

Responsibilities:

• Excellent employment opportunity for a Senior Scientist Safety Assessment in the Waltham MA area. (onsite)
• Utilize human small intestinal organoids to assess the role of therapeutic targets and pathways on the proliferation of normal human intestinal cells.
• Independently design in vitro studies to characterize chemical leads at the molecular level and support their design selection and development towards candidate drugs.
• Perform in vitro studies to assess the use of intestinal organoids from preclinical species (rat dog and nonhuman primate) to predict human toxicities caused by small molecule oncotherapeutics.
• Independently interprets and reports data with a clear understanding of its reliability and draws authoritative conclusions and recommendations.
• Work collaboratively in a matrix organization to deliver shared goals.
  

Experience:

• A PhD in Molecular Biology Pharmacology Toxicology or relevant field and 3 years postdoctoral research experience.
• Experience in the Pharmaceutical industry is a plus.
• Proven experience and expertise in Molecular and Cellular Biology
• Research experience in Stem Cell Biology 3D culture systems including organoids and/or singlecell approaches would be an advantage.
• Experience investigating mechanistic toxicology and/or gastrointestinal biology is a plus.
• A strong publication record demonstrating scientific excellence applying molecular techniques to advance understanding of cellular biology
• Ability to work in a fastpaced team environment with strong communication organization collaboration and leadership skills.
• A social personality that contributes to an open positive collaborative working climate and a strong desire to drive personal development.