2 ERC-funded postdoctoral positions focusing on therapeutic brain delivery
صاحب العمل نشط
حالة تأهب وظيفة
سيتم تحديثك بأحدث تنبيهات الوظائف عبر البريد الإلكتروني
حالة تأهب وظيفة
سيتم تحديثك بأحدث تنبيهات الوظائف عبر البريد الإلكتروني
الوصف الوظيفي
Join the Barriers in Inflammation lab led by Roosmarijn Vandenbroucke at the VIBUGent Center for Inflammation Research () for exciting postdoctoral opportunities! Our team of approximately 20 researchers is dedicated to unravelling the underlying causes of CNS disorders identifying therapeutic targets and assessing their potential for intervention.
Job description
Were offering two postdoctoral positions funded by an ERC project aimed at revolutionizing therapeutic delivery into the brain via the bloodCSF barrier. Our pioneering research harnesses the power of singledomain antibodies also known as nanobodies or VHHs as a Trojan horse for targeted brain delivery. Our goal is to explore the vast potential of VHHs in effectively transporting diverse cargos ranging from proteins to nucleic acids and nanoparticles across the bloodCSF barrier offering promising solutions for a myriad of neurological disorders. We previously identified a promising candidate that requires further optimization and validation and in addition we aim to discover novel VHHs capable of crossing the bloodCSF barrier and delivering therapeutic cargoes to the brain.
Profile
You will become an integral part of a subteam collaborating with an experienced lab technician and a dedicated PhD student whose project focuses on in vitro screening methods using a.o. organoids. We are looking for individuals with expertise in the following specific profiles to enhance and complement the team:
Profile 1
Ph.D. in Pharmaceutical sciences or related fields.
Demonstrated expertise in:
- Drug delivery.
Profile 2
Ph.D. in Molecular biology or related fields.
Demonstrated expertise in:
- In vitro and/or in vivo phage display;
- Cloning engineering expression purification and characterization of VHHs.
We invite applications from dynamic individuals with a strong drive for innovation and motivation. Ideal candidates will possess critical thinking abilities excellent oral and written communication skills in English and a collaborative mindset. Additionally they should demonstrate the capacity to independently plan and execute research with precision. A keen interest in drug delivery nanobodies neuroinflammation and/or brain barriers is essential accompanied by handson experience in molecular biology and/or biochemistry techniques. Proficiency in advanced microscopy in vitro cell culture and organoidbased brain barrier models and/or experience with in vivo mouse experiments (Felasa C) will be considered advantageous. If you are passionate about pioneering research at the intersection of neuroinflammation and therapeutic innovation we encourage you to submit your application.
Join us to undertake a highly innovative project that combines cuttingedge approaches including stateoftheart imaging techniques pluripotent stem cell models in vivo mouse models of neurological disorders drug (brain) delivery and nanobody development.
We offer
- A stateoftheart laboratory environment.
- A versatile and challenging academic position with very diverse contacts in a worldclass research environment operating at an international level and various opportunities to broaden your expertise.
- Opportunities to train in many cuttingedge technologies.
- Training courses in academic technical and career skills.
- A competitive salary and a range of benefits including a bicycle allowance and eco vouchers.
- An initial 1year contract which can be extended up to 5 years.
Starting Date: as soon as possible.
How to apply
Interested candidates can apply through the VIB online application tool.
A complete application file (English) should contain the following documents:
- a 1page summary of your motivation for the position your research experiences and future goals
- a detailed CV including publication list
- contact information of 23 references
The first review of applications will start immediately. A shortlist of applicants will be selected and invited for interviews. The position remains open until a suitable candidate is found.
For further information and questions please send an email to Roosmarijn Vandenbroucke ().
نوع التوظيف
دوام كامل
