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Systems Engineer II (PCRqPCRSequencingtroubleshhoting)


Job Location:

Santa Clara County, CA - USA

Monthly Salary: Not provided by the employer
Posted: 21 July 2026 (30+ days ago)
Application Deadline: 18 October 2026
Vacancies: 1 Vacancy

Job Summary

Our client a world leader in biotechnology and gene therapy is looking for an Systems Engineer II based in Santa Clara CA.


Job Duration: Long Term Contract (Possibility Of Extension)

Pay Rate : $57/hr on W2


Company Benefits: Medical Dental Vision Paid Sick leave 401K


Client is seeking a hands-on Systems Engineer II to support the development and integration of next-generation sequencing (NGS) solutions. This role will work with the Single Molecule Sequencing platform to optimize workflows perform wet-lab experiments troubleshoot system and assay issues and support verification and validation activities.


Key Responsibilities

  • Design execute analyze and document experiments supporting NGS feasibility development integration verification and validation.
  • Perform nucleic acid extraction sample preparation library preparation and sequencing experiments.
  • Optimize sequencing workflows and operating protocols.
  • Troubleshoot instrument assay and workflow failures using root cause analysis.
  • Develop and execute test cases based on product requirements.
  • Apply statistical analysis and Design of Experiments (DoE) methods to interpret data and improve sequencing performance.
  • Collaborate with assay instrumentation software bioinformatics and systems engineering teams.
  • Maintain accurate laboratory records and support continuous improvement of sequencing performance reliability throughput and reproducibility.


Required Qualifications

  • Bachelors degree with 5 years of relevant experience or Masters degree with 13 years of relevant experience in science engineering chemistry or a related field.
  • Hands-on experience with PCR nucleic acid extraction DNA sequencing sample preparation library preparation and/or NGS.
  • Experience using Python MATLAB Git or similar tools for data analysis or automation.
  • Knowledge of statistical analysis including JMP regression and ANOVA.
  • Experience with Design of Experiments (DoE) and statistical process control.
  • Strong troubleshooting root cause analysis data analysis and technical documentation skills.



If interested please send us your updated resume at

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Required Skills:

(NGS or next generation sequencing or sequencing or sequencer or library prep or library preparation or PCR or qPCR or sample prep or nucleic acid extraction) and (troubleshooting OR troubleshoot OR root cause analysis OR failure analysis OR system verification OR system validation OR verification OR validation OR V&V) AND (Python OR MATLAB OR JMP OR Design of Experiments OR DoE OR ANOVA OR regression OR statistical analysis OR statistical process control)