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Structural Biology Research Scientist

Guidehouse


Job Location:

Bethesda, MD - USA

Monthly Salary: $ 85000 - 141000
Posted: 11 July 2026 (30+ days ago)
Application Deadline: 8 October 2026
Vacancies: 1 Vacancy

Job Summary

Job Family:

Biologist


Travel Required:

None


Clearance Required:

Ability to Obtain Public Trust

What You Will Do:
We are seeking a Structural Biology Research Scientist to supportthe National Institute of Allergy and Infectious Diseases (NIAID)through viral protein construct design expression optimization protein purification and cryo-electron microscopy studies that advance vaccine development. Ideal candidates will bring structural virology experience and skills in assay development data analysis reporting and mentorship.This is a full-time on-site opportunity in Bethesda MD.

Responsibilities:

  • Design and generate expression constructs for viral proteins (e.g. envelope glycoproteins capsid proteins regulatory proteins).

  • Develop andoptimizeexpression systems (mammalian insect or stable cell lines).

  • Purify proteins using chromatography methods (affinity SEC ion exchange).

  • Perform binding and antigenicity assays (e.g. ELISA BLI SPR)

  • Conduct biochemical and biophysical characterization (e.g. SEC-MALS DLS)

  • Prepare samples and optimize vitrification conditions for cryo-EM studies

  • Operate and/or coordinate use of cryo-EM instruments (e.g. Titan Krios Glacios)

  • Prepare technical reports figures and manuscripts


What You Will Need:

  • PhD in Structural Biology or a related field

  • Microsoft Office

  • Technical experience needed to assist in studying the basic principles of plant and animal life.

  • Technical support and troubleshooting of sophisticated equipment.

  • At least 2 (two) years of experience

  • Must be able to obtain and maintain a Federal or DoD public trust; candidates must obtain approved adjudication of their public trust prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred

What Would Be Nice To Have:

  • Previous experience supporting NIH

The annual salary range for this position is $85000.00-$141000.00. Compensation decisions depend on a wide range of factors including but not limited to skill sets experience and training security clearances licensure and certifications and other business and organizational needs.


What We Offer:

Guidehouse offers a comprehensive total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

  • Medical Rx Dental & Vision Insurance

  • Personal and Family Sick Time & Company Paid Holidays

  • Parental Leave

  • 401(k) Retirement Plan

  • Group Term Life and Travel Assistance

  • Voluntary Life and AD&D Insurance

  • Health Savings Account Health Care & Dependent Care Flexible Spending Accounts

  • Transit and Parking Commuter Benefits

  • Short-Term & Long-Term Disability

  • Tuition Reimbursement Personal Development Certifications & Learning Opportunities

  • Employee Referral Program

  • Corporate Sponsored Events & Community Outreach

  • annual membership

  • Employee Assistance Program

  • Supplemental Benefits via Corestream (Critical Care Hospital Indemnity Accident Insurance Legal Assistance and ID theft protection etc.)

  • Position may be eligible for a discretionary variable incentive bonus

About Guidehouse

Guidehouse is an Equal Opportunity EmployerProtected Veterans Individuals with Disabilities or any other basis protected by law ordinance or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

If you have visited our website for information about employment opportunities or to apply for a position and you require an accommodation please contact Guidehouse Recruiting at 1- or via email at . All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.

All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @ or . Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse. Note that Guidehouse will never charge a fee or require a money transfer at any stage of the recruitment process and does not collect fees from educational institutions for participation in a recruitment event. Never provide your banking information to a third party purporting to need that information to proceed in the hiring process.

If any person or organization demands money related to a job opportunity with Guidehouse please report the matter to Guidehouses Ethics Hotline. If you want to check the validity of correspondence you have received please contact . Guidehouse is not responsible for losses incurred (monetary or otherwise) from an applicants dealings with unauthorized third parties.

Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse and Guidehouse will not be obligated to pay a placement fee.


Required Experience:

IC


About Company

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Guidehouse is the only scaled advisory consultancy in the world to fully integrate commercial and public or government businesses within each of our industry segments because complex problems require both perspectives to address and outwit.

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