SrExec Director Clinical Development

Erascais a clinical-stage precision oncology company focused on discovering developing and commercializing medicines for the benefit of patients with cancer. Our programs take novel approaches to shutting down one of cancersmost commonly mutated signaling cascades the RAS/MAPK pathway which affects approximately 5.5 million lives each year worldwide. The name Erasca has an important embedded meaning: it is a contraction of our audacious hope to erase cancer that drives our mission and everything that we do on behalf of patients with cancer.

PositionSummary:

Reporting to theChief Medical Officer theSenioror ExecutiveDirector ClinicalDevelopment willdrive the clinical aspects of late-stage clinical development studies or programs.This person willwork closely withcross-functional teamsin the management and execution of theClinical Development Plan (CDP) in developing innovative and efficient solutions to medical and scientific clinical trial issues andinensuring the successful execution and completion of clinical trials.The Senioror ExecutiveDirector ClinicalScience willalsohave individual study level responsibilityfor one or more trials.

Essential Duties and Responsibilities:

• Lead in the planning and execution of clinical studies to successfully move the program through pivotal trialsandeventual submission regulatory approval and launch.
• Key clinical deliverables include document development (INDs Protocols IBs applicable regulatory documents etc.) medical and scientific input into the development of deliverables required for study activation and study conduct (CRFs SAP data listings etc.) data review and other deliverables as needed.
• May attend and contributeatmeetings with Health Authorities (HAs) related to program; developresponses to HAs and IRBs on clinical/medical questions.
• Represent Erasca externally at scientific meetings and congresses.
• Establish andmaintainstrong relationships with internal teams clinical investigators regulatory agencies and key stakeholders.
• Gatheranalyzeand interpret clinical dataprovidingstrategic insights to inform critical decisions and guide program development.
• Manage clinical development timelines effectively ensuring efficient resource allocation and achievement of milestones.
• Perform all duties in keeping with the Companys core valuespoliciesand all applicable regulations.

Required Education and Experience:

• Undergraduate degree;PhD PharmD or other relevant advanced degree in a health science fieldhighly preferred.
• At least10years of biotech or pharmaceutical industry experience as a clinical scientist or in acloselyrelated clinical development function.
• Extensive experience in oncology clinical trials;late-stagedevelopment experienceearly developmentexperiencea plus.
• Experience leading clinical development contributions to regulatory submissions (e.g. (NDA PIP/PSP label negotiation Breakthrough Therapy Designation Accelerated Review) highly preferred.
• Experience in dynamicstartup or small company environments.
• Demonstrated ability to contribute to strategic clinical planning and work effectively independently and oncross-functional teams.
• Demonstrated ability to evaluate interpret and present complex scientific data.
• Deepknowledge of biostatistics GCP and regulatory requirements for clinical studies;extensiveexperience with data analysis and interpretation;understanding of safety and pharmacovigilance principles.
• Excellent verbal and written communication and presentation skills.
• Demonstrated ability to achievehigh performancegoals and meet deadlines in a fast-paced environment; a collaborative team player with a can-do attitude and the ability toidentifyand implement creative solutions to complex problems.
• Flexibility withthe willingnessand ability tomanage throughstrategic shifts.
• Strong learning orientation curiosity andcommitmenttoscience and patients.

The anticipated salary range for this position is $265000 to $310000. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job type and length of experience within the industry education etcetera. In addition to base salary the hired applicant will be eligible to receive an annual bonus and an equity grant at hire and annually in the form of the option to purchase stock in the future for a specified price.

Along with our casual collaborative and fun work and the chance to make your mark in our mission to erase cancer Erasca offers a comprehensive and competitive benefits package that includes: Paid Time Off Holiday and Sick Leave Medical Dental and Vision Plans Short- and Long-Term Disability Basic and Voluntary Life/AD&D Coverage Flexible Spending Accounts (FSA HSA and Commute) Critical Illness and Accident Coverage Pet Insurance Employee Assistance Program 401(k) Plan with Erasca contribution and the opportunity to participate in an Employee Stock Purchase Program.

Erasca Inc. is an Equal Opportunity Employer and takes pride in maintaining a diverse and inclusive environment. We do not discriminate in recruitment hiring training promotion or other employment practices for reasons of sex race religion national origin ancestry physical or mental disability protected medical condition genetic information marital status registered domestic partner status age sexual orientation military and veteran status or any other basis protected by federal state or local law or ordinance or regulation.