Sr. Scientist III Pathology Assay Development

MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies.â Our team of 150 dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer. Our products and platforms have attracted multiple partnerships with leading pharmaceutical and biotechnology companies around the globe.

The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics corporate culture promotes an atmosphere of innovation open communication and teamwork where employees can see firsthand how they contribute to the success of the organization.

Summary of Position
The Sr. Scientist I/II - Pathology Assay Development will lead the development optimization qualification troubleshooting and transfer of tissue-based biomarker assays supporting MacroGenics antibody-drug conjugate (ADC) and immunotherapy programs from discovery through IND-enabling studies and early clinical development. The role will focus on single-plex and multiplex immunohistochemistry (IHC) immunofluorescence (IF) in situ hybridization (ISH) digital pathology and fit-for-purpose tissue biomarker workflows.

The Sr. Scientist I/II will work closely with the Senior Director of Pathology and cross-functional partners to generate robust reproducible and biologically meaningful tissue biomarker data that informs target selection patient-selection hypotheses translational strategy safety assessment and development decisions. Final pathologic interpretation tissue biology assessment and clinical-contextual interpretation will remain under pathology leadership.

Responsibilities and Job Duties
Tissue-Based Assay Development
Independently develop optimize qualify validate and troubleshoot single-plex IHC multiplex IHC/IF and ISH assays using FFPE and frozen tissues.
Design fit-for-purpose assay development plans including antibody and reagent selection titration antigen retrieval detection chemistry controls acceptance criteria and reproducibility assessments.
Evaluate assay specificity sensitivity dynamic range precision robustness and tissue-context performance using appropriate positive negative isotype cell-line xenograft and normal-tissue controls.
Identify and resolve pre-analytical and analytical variables related to tissue collection fixation processing sectioning storage staining platforms and reagent performance.
Develop and maintain tissue and cell-pellet control resources to support assay development and routine assay performance monitoring.
Translate exploratory assays into qualified biomarker workflows suitable for nonclinical and clinical research applications.

Digital Pathology and Image Analysis
Perform whole-slide image review quality control and quantitative analysis of tissue biomarker data.
Partner with pathology leadership to ensure that digital outputs are morphologically appropriate analytically sound and aligned with the intended biological question.
Evaluate and implement digital pathology tools and where appropriate AI/ML-enabled image-analysis approaches.

Translational Biomarker Support
Execute tissue-based components of translational biomarker strategies defined with Pathology and Translational Medicine leadership.
Generate target-expression pharmacodynamic mechanism-of-action and tumor-immune microenvironment data across preclinical models and clinical specimens.
Prepare publication-quality images quantitative summaries data visualizations and technical interpretations for internal project teams governance discussions reports and regulatory-supporting documents.

External Partnerships and Assay Transfer
Coordinate assay development qualification validation and sample testing with external CROs and central laboratories.
Draft technical scopes of work review protocols and validation plans monitor study execution assess data quality and troubleshoot technical issues with vendors.
Lead or support assay transfer method bridging and cross-site concordance activities to ensure consistent performance across internal and external laboratories.

Documentation Quality and Laboratory Operations
Author and maintain assay development reports validation summaries SOPs work instructions protocols templates and technical best practices.
Maintain organized assay records raw data digital image libraries annotations reagent inventories and reference materials in accordance with applicable quality and data-integrity expectations.
Support platform evaluation laboratory workflow improvement and adoption of new tissue-based biomarker technologies.
Ensure timely delivery of high-quality data while managing multiple assays program priorities and vendor activities.

Qualifications

Education & Credentials

Sr. Scientist II

• PhD in pathology cancer biology immunology molecular biology biomedical science or a related discipline with 3 years of relevant industry experience
• MS with 8 years of relevant industry experience.
• BS with 11 years of relevant industry experience.

Sr. Scientist I

• PhD in pathology cancer biology immunology molecular biology biomedical science or a related discipline with 0 years of relevant industry experience
• MS with 5 years of relevant industry experience.
• BS with 8 years of relevant industry experience.

Experience
Demonstrated hands-on expertise developing and troubleshooting tissue-based biomarker assays particularly IHC and/or multiplex IF in a biotechnology pharmaceutical academic diagnostic or CRO environment.
Strong working knowledge of FFPE and frozen tissue handling antibody performance assay controls and common sources of staining artifact.
Experience designing fit-for-purpose assay qualification or validation studies and defining objective assay acceptance criteria.
Experience with digital pathology and image-analysis platforms such as HALO QuPath Visiopharm or comparable software.
Ability to independently analyze experimental data troubleshoot complex technical problems document conclusions and recommend next steps.
Strong scientific writing presentation organization and cross-functional communication skills.

Preferred
Experience developing multiplex IHC/IF ISH spatial biology or image-analysis assays for oncology drug development.
Experience supporting ADC immuno-oncology bispecific antibody or T-cell engager programs.
Experience with automated staining platforms and workflows including Ventana/Roche Leica or comparable systems.
Experience with assay transfer vendor oversight clinical biomarker testing or work performed in regulated or quality-controlled environments.
Familiarity with AI/ML-enabled digital pathology computational image analysis or integration of tissue imaging data with molecular and clinical datasets.
Formal training or substantial experience in pathology histotechnology tumor morphology or tissue-based translational research.

Additional Information

The annual rate of pay for this position ranges from $115600 - $176300 for Scientist II and $100800 - $153800 for Scientist I. For non-exempt roles and according to applicable regulations there may be the possibility for overtime pay. This role is eligible for the Companys discretionary bonus and discretionary equity incentives. Eligible employees may participate in the Companys benefits programs including medical / dental / vision / prescription coverage employee wellness resources 401(k) plan with employer match access to an Employee Stock Purchase Plan (ESPP) paid time off & paid parental leave benefits and disability benefits.

The annual pay rate range is described in good faith and the Company believes is the range of possible compensation for this role at the time of this posting depending on the candidates experience qualifications geographic location and other factors permitted by law. The Company may ultimately pay more or less than the posted range and this range may be modified in the future. No amount is considered to be wages or compensation until such amount is earned vested and determinable under the terms and conditions of the applicable policies and plans. The amount and availability of any bonus commission benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole discretion unless and until paid and may be modified at the Companys sole discretion consistent with the law.

Statement

MacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race color national origin sex gender identity sexual orientation religion age disability protected veteran status or any other characteristic protected by federal state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If because of a medical condition or disability you need a reasonable accommodation for any part of the employment process please email or call and/or 711 for TTD/TTY service.

Required Experience:

Senior IC