Sr Associate Scientist, Process Development

At Gilead were creating a healthier world for all people. For more than 35 years weve tackled diseases such as HIV viral hepatitis COVID-19 and cancer working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the worlds biggest health challenges and our mission requires collaboration determination and a relentless drive to make a difference.

Every member of Gileads team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions and were looking for the next wave of passionate and ambitious people ready to make a direct impact.

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Job Description

The Position

At Gilead we are driven by a shared mission to discover develop and deliver transformative therapies for patients with life-threatening diseases. Achieving this mission requires not only scientific excellence but also innovation in how we design execute and interpret process development experiments.

Within Process Development and Manufacturing (PDM) the Purification Development organization is responsible for developing robust scalable and manufacturable downstream processes that enable reliable clinical and commercial supply. As Biologics pipelines grow in complexity we are advancing automation-enabled data-driven purification platforms to accelerate development timelines and strengthen process understanding.

The Opportunity

In this role you will help transform how purification processes are developed by integrating miniaturized high-throughput experimentation with mechanistic and data-driven modeling. You will contribute to the design and deployment of scalable purification screening platforms that enable rapid evaluation of resin behavior operating conditions and molecule specific interactions using limited material.

By combining robotics advanced analytics and modeling this role supports earlier more confident technical decision-making through improved assessment of purification risk robustness and manufacturability across the development lifecycle. You will work closely with purification scientists automation engineers analytical teams and data scientists with opportunities to influence platform strategy and impact multiple programs across the Biologics portfolio.

Key Responsibilities

Purification Automation & High-Throughput Experimentation

• Design implement and continuously improve automated high-throughput purification assays including miniaturized resin screening and binding studies

• Develop and maintain scalable reproducible robotic workflows using liquid handling and automation platforms

• Translate traditional column scale purification concepts into low-mass high-information screening formats that support rapid decision making

Mechanistic Modeling & Data Driven Insight

• Develop and apply mechanistic models (e.g. adsorption binding kinetics transport phenomena) to interpret purification data and guide experimental design and operating window definition

• Apply multivariate analysis machine learning and statistical modeling to analyze complex datasets identify trends and predict purification performance under varying conditions

• Integrate experimental and computational approaches to improve understanding of resinprotein interactions process sensitivities and scale relevant behavior

Process Development Impact

• Enable early identification of process risks sensitivities and operating windows to support purification process design

• Inform resin selection buffer strategies and process parameters using data driven insights

• Contribute to platform and capability development that benefits multiple programs across the Gilead Biologics portfolio

Collaboration & Communication

• Partner closely with cross functional teams in Purification Automation Analytics and Data Science

• Communicate results clearly through technical reports presentations and data visualizations tailored to diverse audiences

• Contribute to Gilead internal best practices knowledge sharing and long-term technology strategy within Purification Development

Qualifications:

• B.S. with 5 years of industry experience in a relevant scientific discipline (e.g. chemical engineering bioengineering chemistry or biochemistry)

OR

• M.S. with 3 years of industry experience in a relevant scientific discipline (e.g. chemical engineering bioengineering chemistry or biochemistry)

• Strong foundation in protein purification chromatography mechanisms and downstream process development

• Hands on experience with laboratory automation and high-throughput robotics (e.g. Hamilton Tecan or similar platforms)

• Experience designing and executing miniaturized purification binding or screening assays

• Background in mechanistic modeling of purification or related physical/chemical processes

• Demonstrated ability to independently design analyze and troubleshoot complex experimental systems

• Strong problem-solving skills with the ability to connect experimental observations to mechanistic and quantitative understanding

• Excellent written and verbal communication skills with a collaborative and team-oriented mindset

Preferred Qualifications

• Experience applying machine learning multivariate analysis or advanced statistics to experimental datasets

• Proficiency in Python R MATLAB or similar tools for data analysis modeling and automation integration

For additional benefits information visit:

Eligible employees may participate in benefit plans subject to the terms and conditions of the applicable plans.

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