Senior Tissue Engineer

Overview:

Draper is an independent nonprofit research and development company headquartered in Cambridge MA. The 2000 employees of Draper tackle important national challenges with a promise of delivering successful and usable solutions. From military defense and space exploration to biomedical engineering lives often depend on the solutions we provide. Our multidisciplinary teams of engineers and scientists work in a collaborative environment that inspires the cross-fertilization of ideas necessary for true innovation. For more information about Draper visit .

Job Description Summary:

Job Description:

Duties/Responsibilities

• Drive solutions to complex problems with limited direction.

• Contribute to the development of innovative bioengineering solutions propose ways forward and adapt appropriately to changes in requirements.

• Able to provide insight and suggest design modifications based on analysis outcomes.

• Actively mentor less experienced bioengineers and provide thoughtful constructive feedback.

• Performs other duties as assigned.

Skills/Abilities

• Strong foundation in biology and/or engineering principles.

• Team player dedicated collaborative observant and motivated.

• Excellent organizational skills attention to detail and verbal and written communication skills.

• Creative problem-solving skills and a passion for innovation.

• Excellent time management skills with the proven ability to meet deadlines and prioritize tasks.

• Enthusiasm for learning and participating in mentorship/mentoring.

• Proficiency with Microsoft Office Applications.

Education

• A minimum of a Bachelors Degree in Bioengineering Biomedical Engineering Biochemistry Chemistry Cell Biology Immunology Microbiology Molecular Biology Mechanical Engineering Chemical Engineering Physics or related fields is required a PhD is preferred.

Experience

• Requires 5 years of Bioengineering or related engineering experience.

Additional Job Description:

• Develop optimize and characterize mammalian organ-specific micro-physiological (MPS) and organ-on-chip models for toxicity metabolism and/or diseasestate studies; models of interest include brain/CNS liver kidney lung gut vascular and immune
• Apply cell biology developmental biology and tissue engineering fundamentals to establish cell and tissue-based assays within Drapers in vitro tissue culture systems under a variety of use-case scenarios
• Plan conduct and lead in vitro technical experiments in Drapers BSL-2 laboratory using advanced in vitro tissue culture technologies (micro-physiological system or organs-on-chip)
• Culture maintain and manipulate human primary and iPSC-derived cells and tissues across standard in vitro formats and within Drapers proprietary MPS platforms
• Perform broad suite of molecular biochemical and cellular assays (e.g. immunostaining ELISA Luminex flow cytometry DNA and RNA extraction qPCR multi-omics) and biostatical data analysis
• Acquire brightfield fluorescent and high-content confocal microscopy data; process and analyze image sets within automated pipelines to extract quantitative biological insights
• Create version-control and maintain SOPs and analytical methods that are fully compatible within Drapers platform technologies
• Collect interpret and summarize data into clear and concise presentations and technical reports for presentations to project leads internal management external sponsors/customers and for peerreviewed publication
• Collaborate across multidisciplinary teams to execute project plans; mentor and train benchlevel colleagues and foster a collaborative safetyfirst lab culture.
• Troubleshoot experimental challenges in partnership with teammates and project leadership; drive rapid data-backed decisions to keep projects on schedule
• Complete all required training adhere to institutional governmental and safety regulations and champion an environment of compliance
• Contribute to businessdevelopment activities technical ideation proposal writing and customer outreach to expand Drapers tissue engineering portfolio
• Support daytoday lab organization (reagent sourcing material preparation equipment upkeep) to keep the MPS workflow running smoothly
• Work in face-paced milestone-driven interdisciplinary environment where multi-tasking is essential

Preferred qualifications:

• Proven organ-specific expertise: Demonstrated ability to develop and implement advanced in vitro humanderived MPS models (microfluidic devices perfused bioreactors 3D organoids) that meet quantitative organ-specific functional endpoints; organ expertise of interest includes brain/CNS liver kidney lung gut vascular and immune.
• Complex co-culture expertise: Experience integrating nonparenchymal cells (e.g. fibroblasts endothelial immune cell populations) into organ specific-based models to recapitulate complex inflammatory and disease phenotypes; experience with organoid primary and/or iPSC cultures.
• Advancedinvitrosystem fluency: Proven experience with microfluidicbased cell and tissue culture platforms (e.g. micro-physiological systems (MPS) organonchip).
• Broad technical breadth: Some experience with microbiology (viruses bacteria toxins) immunology synthetic biology genetic engineering bioinformatics/data analytics and/or in silico modeling; some experience applying AI/ML-driven cell painting to automate highcontent imaging extract deeplearning phenotypes and integrate quantitative readouts into downstream analyses; some experience with bio-informatic pipelines for high-content image and omics integration (e.g. R/Python); some exposure to in silico PK/PD modeling to link MPS data to in vivo predictions; familiarity with lab-automation for routine laboratory workflows.
• Strong communication skills: Ability to convey complex biology concepts to engineers data scientists and senior management; experienced in multidisciplinary teamwork.
• Proposal development: Experience writing innovative R&D proposals for government sponsors (contracts grants) and secure external funding.
• Professional skills: Demonstrated ability to work independently while thriving in a collaborative environment; demonstrated flexibility to multi-task adapt to shifting priorities and thrive in a fast-moving collaborative environment; prior involvement in industry-academic consortia clinical collaborations and/or successful track-record of securing external funding; experience generating high-impact scientific manuscripts or patent(s).
• Education: PhD in biology or engineering discipline with 3 years of post-doctoral or industry R&D experience or 12 years of experience post MS.

Applicants selected for this position will be required to obtain and maintain a government security clearance.

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The US base salary range for this full-time position is

Our salary ranges are determined by role level and location. The range displayed on each job posting reflects the minimum and maximum target salaries for the position across all US locations. Within the range individual pay is determined by work location and additional factors including job-related skills experience and relevant education or training. Union ranges will be in compliance with the collective bargaining agreements approved rates by location and role. Your recruiter can share more about the specific salary range for your preferred location during the hiring process.Please note that the compensation details listed in US role postings reflect the base salary only and does not include bonuses or benefits.

Our work is very important to us but so is our life outside of work. Draper supports many programs to improve work-life balance including workplace flexibility employee clubs ranging from photography to yoga health and finance workshops off site social events and discounts to local museums and cultural activities. If this specific job opportunity and the chance to work at a nationally renowned R&D innovation company appeals to you apply now is committed to creating an inclusive environment. We understand the value of inclusivity and its impact on a high-performance culture. All qualified applicants will receive consideration for employment without regard to race color religion sex disability age sexual orientation national origin veteran status or genetic information. Draper is committed to providing access equal opportunity and reasonable accommodation for individuals with disabilities in employment its services programs and activities. To request reasonable accommodation please contact .