Senior Systems Engineer

Job Description:

The Sr. IT Systems Engineer designs implements and supports the companys core infrastructure with a focus on Microsoft 365 Azure identity and endpoint management. This role ensures our systems are secure scalable reliable and well-documented to support a growing highly regulated biopharmaceutical environment.

Essential Job Functions

• Own and advance our identity platform including Microsoft Entra ID Azure AD Connect and hybrid identity solutions.
• Design implement and manage modern endpoint management using Intune and Autopilot including application deployment configuration automation and patching.
• Configure and maintain enterprise applications using Entra ID SAML SSO and SCIM provisioning to deliver secure frictionless access.
• Monitor maintain and optimize Windows servers including routine security patching and performance tuning.
• Implement and continuously improve security best practices conduct regular audits and remediate vulnerabilities across systems and endpoints.
• Lead or contribute to complex technical projects collaborating with cross-functional teams to deliver on time and within scope.
• Identify operational issues propose solutions and drive implementation to improve reliability and user experience.
• Manage and resolve advanced incidents and requests including ownership of high-complexity tickets and appropriate escalation to senior leadership when needed.
• Create and maintain clear documentation for system configurations standards and procedures including content needed for risk assessments and validation activities.
• Research and recommend innovative automated approaches to system administration and infrastructure management.

Skills and Qualifications

• Bachelors degree in Computer Science Information Technology or equivalent practical experience.
• Minimum three years of hands-on experience supporting enterprise IT infrastructure.
• Strong experience with Microsoft 365 and Azure services; relevant certifications are a plus.
• Deep understanding of identity and access management (Microsoft Entra ID Azure AD Connect SSO).
• Proven ability to manage Intune-based endpoint management and Autopilot provisioning.
• Strong analytical and critical-thinking skills with a track record of structured problem solving.
• Ability to communicate clearly with both technical and non-technical stakeholders translating technical topics into actionable insights.
• Experience identifying assessing and managing risk across applications and systems in alignment with security and compliance standards.
• Scripting skills in PowerShell Microsoft Graph KQL or similar languages.
• Experience using Copilot PowerPlatform or other AI tools to automate or enhance IT workflows.
• Demonstrated curiosity and a mindset oriented towards innovation and continuous improvement.
• Core Competencies: Interpersonal skills effective communication independent judgment ownership mindset teamwork cross-functional collaboration project management ability to drive work to completion proficiency with Microsoft Office Suite high attention to detail and strong adaptability in a fast-changing environment.

Working Conditions

• Hybrid role based in the Chicago office; minimum of three days per week on site (subject to change at managements discretion).
• May require occasional evening or weekend work and periodic overnight travel as business needs dictate.

The anticipated base salary range for this position is $112000 to $140000.

Xeris Pharmaceuticals Inc. (the Company) is an equal opportunity employer and does not discriminate based on race color religion sex gender identity sexual orientation national origin age disability veteran status genetics or any other characteristic protected by law. All qualified candidates are given equal opportunity and the Companys employment selection decisions are based solely on job-related : This job description is not intended to be all-inclusive. The employee may be required to perform other related duties as needed to meet the ongoing needs of the Company.

The level of the position will be determined based on the selected candidates qualifications and experience. Final determination of the actual base salary offered depends on several factors including but not limited to the candidates skills experience education location and business needs. Employees are eligible for equity or long-term incentive awards where applicable. Field Sales role employees are eligible for a quarterly commission structure. Non-Sales role employees are eligible for an annual bonus. The Company also offers a comprehensive benefits package that includes additional elements such as paid time off benefits various health vision and dental insurance options 401(k) retirement benefits and more for eligible employees. Details about these and other offerings will be provided at the time a conditional offer of employment is made. Candidates are always welcome to inquire about our compensation and benefits package during the interview hired as temporary employees interns and preceptors are not eligible for commissions bonuses and/or long-term incentive or equity awards. Eligibility for other benefits will be based on plan documents.

Accessibility & Reasonable Accommodations

If because of a medical condition or disability you require a reasonable accommodation or assistance to complete any part of the application process please send an e-mail to and identify the type of accommodation or assistance you are requesting. Please include the job requisition number in your message. Please note if your request is not for this stated purpose you will not receive a response to your email. Do not include any medical or health information in this email.

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