Senior Scientist, RNA Delivery
Job Location:
Berkeley, CA - USA
Monthly Salary:
Posted on:
Vacancies:
Job Summary
Experience level: PhD or equivalent industry experience.
About Conception
Conception is pioneering the future of reproductive biology by generating functional human eggs from induced pluripotent stem cells (iPSCs). Our mission is to unlock new possibilities for fertility reproductive health and genetic diversity. We are building a world-class team at the intersection of stem cell biology developmental biology RNA biology and synthetic biology to make this vision a reality.
The position
We are seeking a highly creative rigorous and hands-on Scientist with deep expertise in RNA delivery to help optimize and enhance Conceptions differentiation platform.
This position sits at the intersection of RNA biology delivery technology stem cell differentiation and platform development. You will be responsible for building robust scalable and biologically effective delivery workflows that enable us to test and deploy programs across multiple differentiation contexts.
What youll do
Develop RNA delivery workflows for payload expression in different cell types and culture set ups. Apply RNA delivery strategies to improve and accelerate Conceptions differentiation platform.
Optimize RNA format delivery chemistry and formulation dose timing repeat delivery expression viability and biological activity.
Build assays to measure delivery efficiency target expression and differentiation outcomes. Support screening workflows for RNA constructs genes of interest delivery conditions and combinatorial perturbations.
Collaborate across differentiation cell engineering and computational teams.
What were looking for
Required
PhD or equivalent experience in RNA Biology Cell Biology Stem Cell Biology Bioengineering Synthetic Biology Developmental Biology or a related field.
Hands-on experience delivering RNA into mammalian cells in various formats.
Experience with most up to date RNA delivery technologies (LNPs ligand conjugates exosomes electroporation etc.) and standard readouts such as flow cytometry imaging qPCR reporter assays or RNA-seq.
Experience delivering RNA or nanoparticles into complex culture systems.
Experience optimizing delivery parameters such as dose formulation timing repeat dosing expression duration toxicity and biological effect.
Strong experimental design troubleshooting documentation and data interpretation skills.
Preferred
Experience with iPSCs ESCs primary cells differentiating cells or other difficult-to-transfect cell types.
Experience using RNA-based differentiation approaches.
Experience with different RNA format design production purification characterization or delivery.
Experience with medium- or high-throughput screens ORF libraries combinatorial perturbations or barcoded workflows.
Familiarity with scRNA-seq or related single-cell approaches.
Familiarity with developmental biology reproductive biology germ cell development ovarian biology or organoid systems.
Come and work with us
We are well funded and well connected in Silicon Valley. We offer competitive pay company equity and excellent healthcare benefits for these positions.
To learn more about the original mouse proof of concept to live birth that inspired us see Experience:
Senior IC
About Company
First published in 1869, Nature is the world’s leading multidisciplinary science journal. Nature publishes the finest peer-reviewed research that drives ground-breaking discovery, and is read by thought-leaders and decision-makers around the world.
