Scientist

Legend Biotech is a global biotechnology company dedicated to treating and one day curing life-threatening diseases. Headquartered in Somerset New Jersey we are developing advanced cell therapies across a diverse array of technology platforms including autologous and allogenic chimeric antigen receptor T-cell T-cell receptor (TCR-T) and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world we apply these innovative technologies to pursue the discovery of safe efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen one of the pharmaceutical companies of Johnson & Johnson to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking a Senior Scientist as part of the R&D Leadership Development Program based in Philadelphia PA.

Role Overview

The Early Career Leadership Program at Legend Biotech is a strategic enterprise-focused development experience designed to accelerate the growth of high-potential professionals early in their careers. Rooted in our commitment to cultivating enterprise-minded value-driven leaders this program provides structured rotational exposure executive mentorship and real-time business impact across scientific operational and corporate functions.

The R&D Hi-Po Leadership Development Program is a project-based enterprise leadership accelerator designed for high-potential PhD graduates who aspire to shape the future of cell and gene therapy.

This immersive experience is built to cultivate scientific leaders capable of translating discoveries into development advancing complex pipeline programs and influencing cross-functional strategy. Participants will gain enterprise exposure executive mentorship and access to a formal Annual Leadership Development Series focused on strategic thinking regulatory and clinical acumen and senior leadership readiness. Join us in advancing the frontiers of cell and gene therapywhere your discoveries can redefine treatment paradigms and transform patient outcomes worldwide

We are seeking a highly motivated Scientist to join our growing In Vivo CAR-T Cell Therapy team. The successful candidate will contribute to the development of our in vivo CAR-T platform and pipeline by leveraging expertise in cellular immunotherapy virology and immunology. This role requires scientific excellence strong collaboration skills and the ability to drive projects in a fast-paced environment.

Join us in redefining whats possible and build a career where your growth and patient impact go hand in hand.

Key Responsibilities

• Design and execute research projects to drive innovation of cell and gene therapy platforms and advance pipeline development.
• Develop and optimize assays including but not limited to lentiviral vector production and titration advanced multi-parameter flow cytometry Incucyte ELISA cytotoxicity assays and PCR-based analyses.
• Conduct in vitro and in vivo studies to evaluate potency function and safety of drug candidates.
• Collaborate closely with cross-functional teams to evaluate novel designs and generate robust reproducible and data-driven conclusions.
• Analyze interpret and document experimental results in a timely and highly organized manner maintaining accurate scientific records and ensuring data integrity.
• Contribute to scientific strategy experimental planning and technology innovation to support pipeline advancement.

Requirements

• PhD in Immunology or a related discipline.
• Minimum of 3 years of experience in cell and gene therapy research with experience in CAR-T cell therapy strongly preferred.
• Strong hands-on experience with cellular immunology viral vector technologies and functional assay development.
• Demonstrated scientific productivity through publications patents or equivalent achievements.
• Strong experimental design data analysis troubleshooting and problem-solving skills.
• Excellent verbal and written communication skills with the ability to effectively present complex scientific concepts to diverse audiences.
• Passion for advancing next-generation cell and gene therapies.
• Strong sense of scientific ownership accountability and attention to detail.
• Commitment to continuous learning and staying current with emerging scientific and industry developments.
• Strong team-oriented mindset with a willingness to mentor and support colleagues.
• Ability to thrive in a dynamic fast-paced and highly collaborative environment.

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Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.

Work Authorization & Employment Eligibility

Applicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations we participate in the E-Verify program. If you are selected for employment you will be required to complete the Form I-9 process and your employment eligibility will be verified through E-Verify in accordance with applicable federal law. We are committed to providing a fair transparent and welcoming hiring experience for all candidates.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race color creed religion national origin ancestry citizenship status age sex or gender (including pregnancy childbirth related medical conditions and lactation) gender identity or gender expression (including transgender status) sexual orientation marital status military service and veteran status disability genetic information or any other protected characteristic under applicable federal state or local laws or ordinances.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.