Senior Scientist – In Vivo Neuroimmunology

Job Description

Our companys Neuroscience is recruiting a Sr. Scientist in our Neuroimmunology team in Boston MA to lead in vivo model development and validation to advance novel immune-based therapies for CNS diseases. As a Sr. Scientist you will apply your expertise to evaluate PK/PD and disease-relevant endpoints in murine models to advance pipeline programs. This lab-based role requires independent ownership of study design execution sample processing and evaluation data analysis and clear communication of results to cross-functional project teams and stakeholders. The successful candidate will be able to work independently as well as proactively collaborate with colleagues to generate high-impact data to drive decision making and advance drug discovery.

Key responsibilities of the In Vivo Neuroimmunology Sr. Scientist include:

• Design execute and report murine in vivo studies addressing target validation mechanism of action PK/PD and translational biomarkers; take endtoend ownership of study planning and documentation.

• Perform and supervise dosing (IV IP PO SC and other routes) blood collection cardiac perfusion and careful dissection/collection of CNS and peripheral tissues.

• Prepare and fractionate tissues for biochemical and molecular assays (soluble/insoluble protein fractions) and execute immunoassays and RNA analyses (e.g. ELISA OLINK NULISA western blot flow cytometry qPCR/RTqPCR bulk and single-cell RNA sequencing).

• Process curate and analyze datasets; apply statistical and computational tools to generate figures study reports and presentations that inform program decisions.

• Troubleshoot and optimize experimental and analytical workflows validate new methods ensure reproducibility and maintain accurate records.

• Communicate results clearly to project teams and the broader scientific community (internal reports presentations and publications) and uphold laboratory safety animal welfare and regulatory compliance while collaborating across functions and with external partners.

Work environment and travel:

• This is an onsite laboratory position based in Boston. Occasional travel (<10%) may be required.

QUALIFICATIONS:

Education:

• Masters (with 5 years) or Ph.D. (with 1 year) in Neuroscience Molecular Cell Biology Pharmacology Biology or related field with relevant experience

Required Experience and Skills:

• Demonstrated handson experience designing and executing rodent in vivo experiments including stereotaxic surgeries (intracerebral and intracerebroventricular injections)

• Proficiency with multiple routes of dosing blood collection methods cardiac perfusion and dissection of CNS (discrete brain regions spinal cord) and peripheral tissues

• Practical experience preparing tissue fractions (soluble/insoluble proteins) and performing biochemical and molecular assays (e.g. ELISA OLINK NULISA western blot RNA sequencing or qPCR)

• Experience independently analyzing and visualizing experimental data including from multiplexed platforms

• Strong written and oral communication skills; ability to prepare study reports and present findings to diverse audiences

• Ability to work independently within a collaborative crossfunctional team

Preferred Experience and Skills:

• Industry drugdiscovery experience in pharmaceutical or biotech settings

• Handson proficiency with murine procedures including CSF collection and osmoticpump implantation/management

• Experience with inflammatory and neurodegenerative transgenic mouse models or with PK/PD and doseresponse study design/interpretation

• Experience designing and executing sequencing studies (i.e. bulk RNAseq scRNAseq or snRNAseq) working knowledge of data analysis tools (Python and/or RStudio preferred) and experience generating figures/reports

• Experience mentoring or supervising earlycareer scientists and collaborating across functional teams

• Record of contributions to scientific publications or presentations

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The salary range for this role is

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including but not limited to relevant education qualifications certifications experience skills geographic location government requirements and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive if applicable.

We offer a comprehensive package of benefits. Available benefits include medical dental vision healthcare and other insurance benefits (for employee and family) retirement benefits including 401(k) paid holidays vacation and compassionate and sick days. More information about benefits is available at can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

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