Senior Scientist I, Analytical Development Mass Spectrometry tLNP CMC

The Analytical Development group within the Targeted LNP (tLNP) CMC Development Team at AbbVie is dedicated to advancing state-of-the-art analytical capabilities for tLNP therapeutics development. Our team provides critical support to tLNP drug substance drug product and formulation development. We leverage advanced biophysical separation and mass spectrometry techniques to deeply characterize antibodies mRNA lipids and intact LNP particles. We are building a strong team of scientists who will be instrumental in developing and deploying the analytical toolbox needed to deliver high-quality innovative tLNP medicines to patients.

Position Overview: 

As the mass spectrometry SME within the Analytical Development group of tLNP CMC Development team you will work in an innovative analytical research and development lab and develop LC-MS method for characterizing biotherapeutic products to support tLNP development with an emphasis on mRNA and oligonucleotide analysis. The successful candidate will have hands-on analytical method development experience of LC-MS analysis. Additionally the candidate must foster productive collaborations within the global Analytical CMC organization and with R&D cross-functional partners such as Discovery Process Chemistry Process Engineering Drug Product Development and Quality Assurance and CMC-Regulatory Affairs.

Responsibilities:

• Operate maintain and troubleshoot mass spectrometry (Orbitrap TOF) and liquid chromatography platforms along with general laboratory equipment.
• Document instrument performance organize regular maintenance and coordinate with service engineers during maintenance and troubleshooting activities.
• Lead and execute characterization activities to evaluate and elucidate critical quality attributes of mRNA such as 5 capping efficiency 3 polyA tail distribution and oligonucleotide sequence mapping.
• Provide analytical support for cross-functional teams including formulation development upstream/downstream process development and manufacturing to solve drug development challenges.
• Proactively advance LC-MS characterization of biotherapeutics by developing innovative techniques that address evolving developmental needs and improve operational efficiency.
• Independently conduct sample preparation and LC-MS analyses in compliance with SOPs and document experimental procedures and results in electronic laboratory notebook (ELN).
• Author and review regulatory submission documents such as IND and comparability study.

Qualifications :

• Ph.D. in Analytical Chemistry Biochemistry Pharmaceutical Sciences or a closely related field with 0-3 years of industry experience.
• Previous experience with mRNA oligonucleotide antibody and LNP analysis by LC-MS is a strong plus.
• Experience in mRNA 5 capping and 3 polyA tail LC-MS analysis is preferred.
• Proficient in operating and maintaining mass spectrometry equipment particularly LC-MS systems and have experience in troubleshooting and maintaining LC-MS instruments including tasks like changing and cleaning interfaces.
• Experience with LCMS data acquisition and analysis software such as XCalibur Protein Metrics FreeStyle Skyline BioPharma Finder and MassLynx.
• Organized detail-oriented and committed to maintaining proper documentation.
• Work independently while also collaborating effectively with a team of experts.
• Hands-on experience with additional analytical techniques relevant to mRNA or LNP analysis is a plus.
• Strong presentation and communication skills with the ability to explain data to technical and non-technical audiences.

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors  including  geographic location and we may ultimately  pay more or less than the posted range. This range may be  modified in the future. 

• We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.

• This job is eligible to  participate in our short-term incentive programs. 

Note: No amount of pay is  considered to be wages or compensation until such amount is earned  vested  and determinable. The amount and availability of  any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a   particular employee remains in the Companys sole and absolute discretion unless and until paid and may be  modified at the Companys sole and absolute discretion consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

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Work :

No

Employment Type :

Full-time