Senior Scientist, Discovery Chemistry

Why Sarepta Why Now

The promise of genetic medicine has arrived and Sarepta is at the forefront. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle central nervous system and cardiac 2023 we launched our fourth therapy and the first ever gene therapy to treat Duchenne.

Were looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.

What Sarepta Offers

At Sarepta we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:

• Physical and Emotional Wellness

• Financial Wellness

• Support for Caregivers
  

For a full list of our comprehensive benefits see our website: Importance of the Role

The RNA Research group at Sarepta Therapeutics is seeking a talented motivated and experienced scientist to join the dynamic and fast-paced discovery chemistry team located in Bedford MA. The successful candidate will work on our PMO & siRNA oligonucleotide platform and discovery research on improved delivery of oligonucleotides as well as manage collaborations and CROs as needed. This position will work closely with Discovery Biology Translational Sciences Research Operations Business Development and Legal teams to implement new drug discovery programs and advance next generation of RNA therapeutics.

The Opportunity to Make a Difference

• Design and conduct novel oligonucleotide conjugates synthesis purification and characterization; Apply state-of-the-art delivery methods to achieve in vivo proof of concept; Develop efficient and scalable synthetic methods and routes.
• Develop and utilize innovative synthetic medicinal chemistry and/or chemical biology problem solving skills coupled with analysis of diverse data sets to build structure-activity relationships.
• Act as key member of a multidisciplinary RNA research team assisting with development of project strategy and analysis and communication of complex data.
• Serves as an in-house oligonucleotide and delivery chemistry expert.
• Drive the writing of technical reports to support patent applications and manuscript preparations.
• Coordinate and manage collaborations and CRO operations to ensure deliverables meet project needs.
• Organize workstreams and complete individual and team objectives to maintain project timelines.
• Supervise and mentor junior staff.

More about You

• The ideal candidate will have a PhD in organic chemistry biochemistry or related fields with 5 years of relevant post-doctoral or industry experience.
• Strong experience in organic chemistry and multi-step organic synthesis is a must; Hands-on experience with manual and automated systems for solid-phase synthesis of peptides and nucleic acids is essential for this role.
• Previous experience in the design chemical optimization and formulation/delivery of peptides and/or oligonucleotide therapeutics is highly desirable.
• Experience with using analytical techniques/instrumentation for peptides and/or oligonucleotides purification and characterization such as Reverse Phase (HPLC/UPLC) MALDI-TOF and Liquid Chromatography Mass Spectrometry (LC-MS) is a plus.
• Handson experience in computational chemistry including CADD structurebased design ligandbased modeling or other predictive computational frameworks is strongly preferred.
• Track record with the ability to execute multiple concurrent research projects within a cross-functional team environment.
• Solid written and oral communication skills enthusiasm integrity self-motivation strong interpersonal skills and attention to detail are necessary.

What Now

Were always looking for solution-oriented critical thinkers.

So if youre comfortable with ambiguity and candor relish challenging yourself and place kindness and integrity at the forefront of how you approach your peers and work then we encourage you to apply.

#LI-Onsite

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This position requires work on site at one of Sareptas facilities in the United States.

The targeted salary range for this position is $112000 - $140000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sareptas compensation philosophy and considers factors including but not limited to education training experience external market conditions criticality of role and internal equity.

Candidates must be authorized to work in the U.S.

Sarepta Therapeutics offers a competitive compensation and benefit package.

Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.