Senior Scientist, Biology-Discovery

Job Description

We are seeking a highly qualified and motivated Senior Scientist to join the Discovery Oncology team in Boston. The ideal candidate must possess a strong scientific foundation excellent technical skills and a track record of contributing to cancer drug discovery research.

This role will support and lead research projects focused on developing cancer therapeutics. The successful candidate will work both independently and collaboratively within multidisciplinary teams to generate high-quality data and advance project goals. Key responsibilities include developing and optimizing assays designing and executing well-controlled experiments analyzing data interpreting results troubleshooting arising issues and generating actionable insights to inform project decisions. The Senior Scientist will present progress updates at internal team and departmental meetings and will contribute to multiple projects simultaneously.

Education:

Ph.D. degree with 0-2 years of postdoctoral or industry experience preferably in cancer biology pharmacology immunology molecular biology biochemistry or related field

Or M.S. degree with 4 years of industry experience

OR B.S. degree with 7 years of industry experience

Required experience and skills:

Demonstrated experience supporting and advancing oncology drug discovery programs through data-driven decision making and contributions recognized through publications presentations or conference abstracts.

Strong hands-on wet lab experience in molecular and cellular biology techniques

Experience with multi-color flow cytometry Incucyte cell viability assays engineering cell line models (e.g. CRISPR shRNA lentiviral transduction etc.)

Experience with protein and biomarker analysis including Western blotting JESS ELISA/ Meso Scale Discovery

Ability to collaborate with in vivo pharmacology teams to support endpoint sample analysis including processing and characterization of tumor and primary tissue samples

Proficiency in data analysis and interpretation with a sound understanding of statistical concepts and software such as GraphPad Prism and FlowJo

Demonstrated ability to work independently to design experiments troubleshoot technical challenges interpret results and recommend next steps

Strong written verbal and presentation skills with the ability to communicate scientific findings effectively to audiences

Preferred experience and skills:

Previous experience working with different therapeutic modalities in an industry setting such as small molecules and biologics

Demonstrated ability to thrive in a highly collaborative cross-functional research environment

#eligibleforERP

Required Skills:

Assay Development Assay Development Biochemical Assays Biologics Biomarkers Biopharmaceuticals Cancer Immunotherapy Cancer Research Cancer Therapy Cell Culture Techniques Data Generation Design of Experiments (DOE) Detail-Oriented Drug Discovery Research Drug Target Identification Experimental Methods Flow Cytometry High Content Screening Immunoassays Immunology In Vivo Models Molecular Biology Pharmaceutical Research Pharmacology Researching 5 more

Preferred Skills:

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US and Puerto Rico Residents Only:

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The salary range for this role is

$119100.00 - $187500.00

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including but not limited to relevant education qualifications certifications experience skills geographic location government requirements and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive if applicable.

We offer a comprehensive package of benefits. Available benefits include medical dental vision healthcare and other insurance benefits (for employee and family) retirement benefits including 401(k) paid holidays vacation and compassionate and sick days. More information about benefits is available at can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only:We will consider for employment all qualified applicants including those with criminal histories in a manner consistent with the requirements of applicable state and local laws including the City of Los Angeles Fair Chance Initiative for Hiring Ordinance

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Merck & Co. Inc. Rahway NJ USA also known as Merck Sharp & Dohme LLC Rahway NJ USA does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place introductions are position specific. Please no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

Yes

Travel Requirements:

10%

Flexible Work Arrangements:

Not Applicable

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

n/a

Job Posting End Date:

09/29/2026

*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.