Senior Scientist, Biology

Company Summary

FL106 Inc. is a privately held early-stage biotechnology company focused on developing novel drug delivery modalities. FL106 is backed by Flagship Pioneering which provides the strategic vision and resources to advance FL106 from platform validation to clinical impact.

Position Summary

We are seeking a highly motivated and experienced Senior Scientist to join our research team. The successful candidate will possess deep expertise in cell isolation and sorting in vivo/in vitromouse studies gene-silencing technologies (siRNA)flow cytometryand advanced microscopy techniques. This individual will play a key role in designing executing and interpreting preclinical studies totherapeutic programs. Depending on experience and demonstrated leadership the candidate may lead research initiatives mentor team members manage external collaborations and contribute to scientific and program strategy.

Key Responsibilities

• Design execute and analyze complex in vitro and ex vivo experiments to support discovery and preclinical research programs.
• Lead and perform multi-parameter flow cytometry assays including panel design optimization troubleshooting and data interpretation.
• Perform and optimize cell isolation and cell sorting (e.g. FACS MACS) from various tissues and biological samples.
• Execute in vivo mouse studies including disease model development dosing tissue collection and phenotypic characterization.
• Develop and apply siRNA-based approaches for target validation pathway interrogation and mechanistic studies.
• Design and perform microscopy-based experiments including fluorescence confocal live-cell and high-content imaging and analyze imaging datasets.
• Utilize complementary molecular and cellular biology techniques to support target validation and mechanism-of-action studies.
• Design analyze and interpret cell profiling experiments using flow cytometry imaging and molecular approaches.
• Contribute to biomarker discovery translational research efforts and preclinical candidate characterization.
• Analyze interpret and present experimental findings to cross-functional teams and senior leadership.
• Generate technical reports presentations study summaries and scientific documentation to support program advancement.
• Collaborate effectively with internal teams CROs academic collaborators and external partners.
• Mentor junior scientists and contribute to a collaborative innovative research environment.
• For Senior Scientist and Principal Scientist levels provide scientific leadership contribute to research strategy and lead cross-functional initiatives.
• Maintain accurate experimental records and ensure compliance with institutional ethical and regulatory guidelines.

Qualifications

• Ph.D. in Cell Biology Genetics Molecular Biology Pharmacology Immunology Biomedical Sciences or a related field with 6 years of relevant experience for Senior Scientist roles; 8 years of industry experience and demonstrated scientific leadership for Principal Scientist roles.
• Alternatively an M.S. degree with substantial relevant industry experience.
• Strong expertise in flow cytometry including cell sorting (FACS) panel design troubleshooting and data analysis using FlowJo or equivalent software.
• Hands-on experience with cell isolation techniques including tissue dissociation and magnetic bead-based separation.
• Extensive experience with mouse models and in vitro experimental techniques.
• Demonstrated expertise in siRNA design delivery optimization and functional validation.
• Hands-on experience with microscopy platforms including fluorescence confocal live-cell and high-content imaging systems.
• Strong quantitative data analysis experimental design and statistical analysis skills.
• Excellent communication presentation and scientific writing skills.
• Ability to work independently and collaboratively in a fast-paced multidisciplinary environment.

Preferred Qualifications

• Experience in translational research drug discovery or preclinical therapeutic development.
• Experience in biotechnology or pharmaceutical industry settings.
• Experience with cell profiling phenotyping and functional assays using primary mouse and human cells as well as established cell lines.
• Experience with single-cell and/or spatial biology technologies including scRNA-seq CITE-seq or spatial transcriptomics.
• Experience managing CROs external collaborators and cross-functional project teams.
• Proficiency with additional molecular and cellular biology techniques including:
• qPCR
• Western blotting
• ELISA and multiplex cytokine assays
• RNA-seq and transcriptomic analysis
• Gene silencing and gene-editing approaches
• Protein overexpression systems
• Immunohistochemistry (IHC) immunofluorescence (IF) and advanced flow cytometry applications
• Experience with image analysis software such as ImageJ/Fiji CellProfiler Imaris or equivalent platforms.
• Experience with computational analysis of flow cytometry imaging or transcriptomic datasets.
• Track record of scientific publications patents and/or successful advancement of therapeutic programs.

About Flagship

Flagship Pioneering is a bioplatform innovation companythat invents and builds platform companies each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000 Flagship has originated and fostered more than 100 scientific ventures resulting in generation of over 500 patents initiation of over 50 clinical trials for novel therapeutic agents and an aggregate value of more than $90 billion. Many of the companies Flagship has founded have addressed humanitys most urgent challenges: vaccinating billions of people against COVID-19 curing intractable diseases improving human health preempting illness and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNEs Change the World list an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Companys annual list of the Worlds Most Innovative Companies. Learn more about Flagship at.

Flagship Pioneering is committed toequal employment opportunityregardless of race color ancestry religion sex national origin sexual orientation age citizenship marital status disability gender identity or Veteran status.

At Flagship we recognize there is no perfect candidate. If you have some of the experience listed above but not all please apply anyway. Experience comes in many forms skills are transferable and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively FSP) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneerings internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $126000 - $160000. Compensation for the role will depend on a number of factors including a candidates qualifications skills competencies and experience. FL106 currently offers healthcare coverage annual incentive program retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL106s good faith estimate as of the date of publication and may be modified in the future.

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