Senior Scientist, Biologics Purification II

Join AbbVies Biologics Discovery Sciences group and make a tangible impact in advancing innovative biologic therapies. As a scientist specializing in Biologics Purification you will play a pivotal role in driving drug discovery collaborating within a dynamic team dedicated to supporting transformative science that improves patient lives worldwide. Your expertise will help deliver high-purity bispecific antibody-based biologic candidates with suitable purity/characteristics to support the advancement of vital in vitro (i.e. drug-like property assays binding cell-based assays etc.) and in vivo studies (i.e. efficacy non-GLP NHP PK DRF etc.). 

Key Responsibilities:

• Lead small-scale (<1L) purification of bispecific antibody biologics to support critical research assays and studies
• Design and execute advanced chromatography techniques and robust bioprocess development strategies to address production impurities and liabilities to deliver high quality biologics to therapeutic areas
• Apply Design of Experiments (DOE) with high throughput automation to optimize chromatography conditions for enhanced separation and resolution of complex protein mixtures
• Leverage AI and programming expertise to design and build data capture workflows and data warehousing infrastructure that supports machine learning development.
• Collaborate with multidisciplinary teams translating molecular insights into functional results
• Stay current with emerging scientific literature to foster innovation and continuous improvement
• Present findings clearly to diverse audiences and document results with rigor

Qualifications :

• BS MS or PhD in Bioinformatics Biophysics Chemical Engineering or related field with typically 12 years (BS) 10 years (MS) or 4 years (PhD) of experience
• Deep proficiency in bioprocessing column chromatography and biotherapeutics manufacturing
• Experience operating high throughput automated liquid handling systems for chromatography applications (i.e. plate-based screening robocolumns)
• Demonstrated success designing and executing DOE studies with successful application to protein production scale-up  
• Experience with chromatography instrumentation and software (i.e. Unicorn) is required
• Experience developing bioinformatics tools and APIs for real-time data acquisition extraction and storage in LIMS environments is preferred.
• Familiarity with programming languages (i.e. Python) and AI/ML tools is a plus
• Strong understanding of molecular and post-translational attributes of biologics
• Exceptional analytical communication and presentation skills
• Collaborative spirit and dedication to scientific excellence

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of thisposting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic locationand we may ultimately pay more or less than the posted range. This range may be modified in the future. 

• We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.

• This job is eligible to participate in our long-term incentive programs. 

Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commissionincentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless anduntil paid and may be modified at the Companys sole and absolute discretion consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

US & Puerto Rico only - to learn more visit  & Puerto Rico applicants seeking a reasonable accommodation click here to learn more:

Work :

No

Employment Type :

Full-time