Senior Scientist 1, Bioassay Development, CMC Biologics, Analytical Research & Development

Senior Scientist 1 Bioassay Development CMC Biologics Analytical Research & Development AbbVie Biotherapeutics Inc. South San Francisco CA: Onsite (onsite 5 days per week).

Key Responsibilities

• Develop & optimize complex bioassays & target-binding potency assays critical for development of complex biotherapeutics.

• Collaborate with analytical teams to elucidate structure/function & interact cross-functionally with teams from Discovery Chemistry Manufacturing & Controls (CMC) QC QA to support drug development activities & IND submissions.
• Qualify/validate/transfer potency methods to external partners & author technical documents (e.g. test methods protocols & reports) to enable regulatory submissions).
• Develop new techniques explore new approaches & technologies perform troubleshooting & optimization experiments & present your work to various cross-functional teams.

Qualifications :

Education & Experience

Must possess a MS degree in biology biochemistry cell/molecular biology or a related field & 1 year of academic research experience or industry work as a development scientist.

Of academic research experience &/or industry work experience required must have 1 year:

1. developing binding potency assays (ELISA TR-FRET Octet flow cytometry other cell-based formats) to characterize & test protein therapeutics (monoclonal antibodies ADCs &/or other biologic modalities);
2. developing cell-based functional potency assays (cytotoxicity assays reporter gene assays proliferation assays effector function activity assays (i.e. ADCC CDC) to characterize & test protein therapeutics (monoclonal antibodies ADCs &/or other biologic modalities);
3. performing cell-based target binding potency assays noncell-based target binding potency assays &/or functional potency assays to characterize drug mechanism of action;
4. using GraphPad PRISM PLA Softmax Pro or similar data analysis software;
5. optimizing & troubleshooting potency assays to improve performance &/or resolve performance issues;
6. working in a matrixed organization within a crossfunctional scientific environment within a (CMC) organization; &
7. authoring technical reports drafting SOPs writing CMC sections of regulatory filings & giving scientific presentations to peers & management.

Alternatively would accept BS Degree in biology biochemistry cell/molecular biology or a related field & 5 years academic research experience &/or industry work experience required as a development scientist.

Of work experience required must have 5 years of academic research experience &/or industry work experience in each of (i) (ii) (iii) (iv) (v) (vi) & (vii).

Work experience may be gained concurrently. Will accept combination of education training & work experience.

Additional Information :

Salary Range: $143067.06 - $162000.00 per year.

Apply online at or send resume to . Refer to Req ID: REF49886M

We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.   This job is eligible to participate in our short-term and long-term incentive programs.

AbbVie is committed to operating with integrity driving innovation transforming lives serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race color religion national origin age sex (including pregnancy) physical or mental disability medical condition genetic information gender identity or expression sexual orientation marital status status as a protected veteran or any other legally protected group status.

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

US & Puerto Rico only - to learn more visit  & Puerto Rico applicants seeking a reasonable accommodation click here to learn more:

Work :

No

Employment Type :

Full-time