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Senior Project Manager


Job Location:

Philadelphia, PA - USA

Monthly Salary: Not provided by the employer
Posted: 29 September 2026 (Yesterday)
Application Deadline: 27 December 2026
Vacancies: 1 Vacancy

Job Summary

AboutIovanceBiotherapeutics Inc.

Iovance Biotherapeutics Inc.isthe global leader in innovating developing and delivering tumor infiltrating lymphocyte (TIL) cell therapies for patients with solid (lifileucel) is the firstFDA-approved one-time treatment for previously treated advanced melanoma now approved in three global markets and available at more than 95 authorized treatment centers. TheIovance TIL platformspans registrational trials and next-generation programs inadditionalsolid tumors including gene-edited and IL-12 tethered TIL therapies next-generation IL-2 and precision immuno-oncology approaches. As the first and only company to take TIL therapy from concept to a broadly accessible commercial treatmentIovanceoperates as an end-to-end cell therapy company anchored by fully owned centralizedU.S.-based manufacturing that is scaled to serve thousands of cancer patients worldwide each year. For more information please .

Amtagvi and its accompanying design marksProleukinIovance and IovanceCaresare trademarks and registered trademarks ofIovance Biotherapeutics its subsidiaries. All other trademarks and registered trademarks are the property of their respective owners.

Information on Iovances broad industry-leading patent portfolio is available on the Intellectual Property page .

Overview

The Senior Project Manager will play a key role in the development management and execution of Iovances manufacturing sites project portfolios in Philadelphia PA reporting to the Senior Director Operational Excellence. This experienced individual will shape project management processes and standards and provide guidance to less experienced project managers. The role will be responsible for planning leading and managing the successful execution of complex cross-functional projects aligned with site and company objectives and priorities. This role will also be responsible for establishing and reporting on key portfolio and project metrics in support of on time and within budget project deliverables.

As a member of the Operational Excellence department this individual will act as a change agent to instill a culture of continuous improvement and support building capabilities to enable individuals and teams to identify opportunities for improvement and independently implement solutions.

Essential Functions and Responsibilities

  • Shape project management processes and standards and provide guidance to less experienced project managers.
  • Engage with senior leaders sponsors and stakeholders to ensure alignment of projects with organizational strategy.
  • Identify and mitigate risks at a portfolio level and develop strategies for risk management that affect multiple projects or the organization.
  • In collaboration with cross-functional teams create establish and maintain integrated project plans.
  • Lead and facilitate complex cross-functional projects with minimal oversight through all life cycle phases: initiation and feasibility planning and design execution and closing.
  • Deliver timely high-quality output on multiple projects simultaneously by utilizing project management skills including clear project charters timeline and budget management data collection and analysis and communication plans. Utilize escalation plans and countermeasures when outcomes timelines or budgets are at risk.
  • Identify interdependencies critical path and at-risk activities anticipate bottlenecks and help remove barriers to progress against department or corporate goals.
  • Establish monitor and report on portfolio and project progress to senior leadership utilizing status / dashboard reports.
  • Act as a subject matter expert coaching all levels of the organization in project management concepts best practices and tool application to increase the capability of the business.
  • Build productive internal and external working relationships with stakeholders in a matrix organization.
  • Identify and initiate process improvements as appropriate.
  • Support the vision of Operational Excellence and act as a change agent to instill a continuous improvement culture throughout the organization.
  • Must adhere to Iovance Biotherapeutics core values policies procedures and business miscellaneous duties as assigned.

Travel

  • May require travel based on business needs

Required Education Skills and Knowledge

  • Bachelors degree in science engineering business or other related field.
  • Project Management Professional or equivalent experience
  • 10 years of industry and supervisory experience. At least 8 years of experience managing and leading multiple complex projects effectively and efficiently in a matrix organization.
  • Ability to use predictive agile and hybrid approaches to determine which way of working is best for each project.
  • Strong communication interpersonal influencing change management and people leadership skills.
  • Proactive results oriented self-starter with attention to detail and the ability to work both independently and collaboratively in a fast-paced setting.
  • Comfortable in a fast-paced small company environment and able to adjust workload based upon changing priorities and ability to manage ambiguity.
  • Proficient with Microsoft Office (Excel PowerPoint and Outlook) Visio and project management software including timeline visualization.

Preferred Education Skills and Knowledge

  • Manufacturing experience ideally in a Biopharmaceutical environment and/or Cell and Gene Therapy.
  • Change Management / Agent Training
  • Lean or Lean Six Sigma certification or training
  • Proficient with Smartsheet

The physical demands described here represent those that an employee must meet to perform the essential functions of this job successfully. Reasonable accommodations may be made upon request to enable individuals to perform essential functions. Please contact Human Resources to request an accommodation.

Physical Demands and Activities Required

  • Must be able to remain in a stationary position standing or sitting for prolonged periods of time.
  • Must be able to move about inside an office and exert up to 10 pounds of force occasionally or a negligible amount of force frequently or constantly to lift carry push pull or otherwise move objects.
  • Must have visual acuity to perform activities such as: preparing and analyzing data and figures viewing a computer screen and extensive reading.
  • This position requires repetitive motion substantial movements (motions) of the wrist hands and/or fingers.
  • Must be able to communicate with others to exchange information.

Mental

  • Clear and conceptual thinking ability; excellent judgment troubleshooting problem-solving analysis and discretion; ability to handle work-related stress; ability to handle multiple priorities simultaneously; and ability to meet deadlines

Work Environment

  • This job works in a professional office environment and a manufacturing lab setting.
  • Potential exposure to latex bleach loud noise lab equipment hazards strong odors and chemical/biochemical is possible.
  • Requires operating standard office equipment and keyboards.

#LI-onsite

The statements contained in this document are intended to describe the general nature and level of work being performed by a colleague assigned to this description. They are not intended to constitute a comprehensive list of functions duties or local variances. Management retains the discretion to add or to change the duties of the position at any time.

Iovance is committed to cultivating and offering a diverse and inclusive work environment. As an equal-opportunity employer our employees and applicants will be considered without regard to an individuals race color religion sex pregnancy national origin age physical and mental disability marital status sexual orientation gender identity gender expression genetic information military and veteran status and any other characteristic protected by applicable law. If you need assistance or accommodation to apply to one of our opportunities please contact .

By voluntarily providing information and clicking Submit Application you explicitly consent to the collection and use of your personal information for the purposes described above and in our Candidate Privacy Notice.



Required Experience:

Senior IC


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Learn about our investigational tumor infiltrating lymphocyte (TIL) therapy. View our clinical trials and pipeline.

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