Senior Principal Scientist, Translational Clinical Biomarkers

Job Description

We are seeking an accomplished and highly motivated Senior Principal Scientist (Sr. Director equivalent) to serve as an Immunology Biomarker Lead within Translational Clinical Biomarkers. This role provides strategic and scientific leadership in the design execution analysis and communication of clinical biomarker strategies across our immune-mediated therapeutic portfolio from discovery to pivotal clinical studies.

The successful candidate will drive decision-centric biomarker strategies that connect drug mechanism disease biology precision medicine pharmacodynamics dose decisions and clinical endpoints directly informing program- and portfolio-level decisions across the development lifecycle.

This role requires strong leadership of multi-disciplinary team efforts through deep scientific expertise structured decision-making sophisticated data analysis & interpretation; and cross-functional collaboration aligning stakeholders in a fast-paced matrixed environment.

Primary Responsibilities:

Strategic Leadership & Program Impact:

• Lead and shape integrated biomarker strategies across discovery early- and late-stage clinical programs ensuring clear hypotheses fit-for-purpose endpoints and explicit linkage to key development decisions in close collaboration with cross-functional leaders particularly in Discovery Late-Stage Clinical Development and across Translational Medicine

• Serve as the biomarker strategy lead within cross-functional program teams and represent multi-disciplinary team(s) in governance forums ensuring biomarker strategies to address mission-critical questions for both forward and reverse translation

• Inform portfolio strategy by advancing biomarker-driven insights that inform target validation patient selection and go/no-go decisions

• Translate disease biology and therapeutic mechanism of action into clinically actionable biomarker strategies addressing critical program questions e.g. proof of biology pharmacodynamic effects precision medicine and surrogate endpoints for efficacy.

• Drive selection and application of innovative biomarker approaches aligned with biological rationale and clinical utility

Cross-functional Leadership & Alignment:

• Lead biomarker sub-teams and related working groups including clinical discovery translational regulatory bio-stats and data sciences

• Collaborate effectively across disciplines to integrate scientific perspectives into cohesive strategies

• Provide scientific leadership to enable hypothesis-driven decision-focused biomarker strategies

• Grow and develop team members including mentorship of direct report(s) and other scientists in the department acting as a role model and culture driver

Data Interpretation & Communication:

• Champion biomarker analysis plans and provide critical scientific input to the interpretation of complex datasets to deliver scientifically rigorous and clinically meaningful conclusions

• Clearly articulate insights to internal stakeholders governance bodies and external scientific audiences

• Support external engagement including publications presentations and KOL interactions as appropriate

NOTE: This role is available in Rahway NJ Boston/Cambridge MA or Upper Gwynedd PA based on candidate preference

QUALIFICATIONS:

Education:

• Ph.D. or M.D. with 12 years in Immunology or related scientific discipline and relevant experience with autoimmune diseases and/or translational medicine

Required Experience and Skills:

• Deep expertise in immunology and immune-mediated/inflammatory diseases with experience in at least one of the following:

  • Gastrointestinal/mucosal inflammation

  • Rheumatology

  • Dermatology

• Proven track record of driving translational strategies that inform clinical development decisions including close cross-functional collaboration and partnership

• Demonstrated ability to lead highly matrixed organizations

• Strong analytical and problem-solving capabilities with the ability to translate complex data into clear decision-oriented insights

• Excellent communication skills including experience presenting to senior leadership and external stakeholders

• Working knowledge with biostatistics bioinformatics and advanced data analytics

• Strategic mindset with a focus on decision impact rather than data generation alone

• Strong leadership presence and ability to influence cross-functional and senior stakeholders

• Proven ability to operate effectively in a fast-moving matrixed environment

Preferred Experience and Skills:

• Experience advancing precision medicine strategies

• Direct managerial experience

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Required Skills:

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The salary range for this role is

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including but not limited to relevant education qualifications certifications experience skills geographic location government requirements and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive if applicable.

We offer a comprehensive package of benefits. Available benefits include medical dental vision healthcare and other insurance benefits (for employee and family) retirement benefits including 401(k) paid holidays vacation and compassionate and sick days. More information about benefits is available at can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

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Los Angeles Residents Only:We will consider for employment all qualified applicants including those with criminal histories in a manner consistent with the requirements of applicable state and local laws including the City of Los Angeles Fair Chance Initiative for Hiring Ordinance

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