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Senior Manager, US Medical Affairs

Dyne Therapeutics


Job Location:

Waltham, MA - USA

Monthly Salary: $ 165000 - 190000
Posted: 22 August 2026 (30+ days ago)
Application Deadline: 19 November 2026
Vacancies: 1 Vacancy

Job Summary

Company Overview:

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) Pompe disease and multiple DMD mutations. At Dyne we are on a mission to deliver functional improvement for individuals families and communities. Learn more at and follow us onXLinkedInandFacebook.

Role Summary:

The Senior Manager US Medical Affairs supports execution of Dynes US Medical Affairs strategy for the Duchenne Muscular Dystrophy (DMD) program. This role contributes to critical launch readiness activities and supports the planning and delivery of US Medical initiatives including KOL engagement congress execution medical education efforts and cross-functional coordination.
The Senior Manager operates as both a scientific and operational contributor helping prepare the US Medical organization for anticipated DMD program needs. This role partners closely with Medical Science Liaisons (MSLs) Global Medical Affairs and cross-functional stakeholders to ensure medical activities are high-quality compliant and impactful.
This role is based in Waltham MA.

Primary ResponsibilitiesInclude:

Medical Strategy Execution & Launch Readiness
  • Supports execution of US Medical Affairs tactical plans for the DMD program
  • Assists in implementing scientific platform materials congress planning and medical education initiatives
  • Contributes to cross-functional launch readiness activities to ensure alignment with program milestones
  • Supports development and deployment of DMD-focused scientific materials disease state education resources and field medical tools
Field Medical & KOL Engagement
  • Partners with the US MSL team to support KOL identification engagement planning insight gathering and field metric tracking
  • Translates field insights into actionable recommendations for Medical Affairs and cross-functional teams
  • Tracks and monitors field activity and engagement effectiveness
Scientific Materials & Medical Review
  • Contributes to development of scientific materials field tools and educational content
  • Provides Medical review for promotional materials through the Promotional Review Committee (PRC)
  • Maintains deep and current scientific knowledge in DMD and Dynes therapeutic platform
Congress & External Engagements
  • Supports planning and execution of medical congresses including onsite activities aligned to DMD milestones
  • Coordinates logistics and execution of US advisory boards and expert engagements
Cross-Functional Collaboration & Compliance
  • Partners with Patient Advocacy Market Access and Commercial teams to support aligned medical activities
  • Ensures all activities comply with US regulatory legal and compliance standards
  • Models Dynes core values through collaboration accountability and scientific integrity

Educationand Skills Requirements:

  • Advanced scientific or clinical degree required (PhD PharmD MD or equivalent)
  • 7 years of relevant Medical Affairs experience in pharmaceutical or biotechnology industry
  • Rare disease experience preferred; neuromuscular disease experience a plusExperience supporting US-based medical tactics congress activities or field medical programs
  • Strong scientific acumen with ability to translate clinical data for diverse audiences
  • Excellent written and verbal communication skills
  • Ability to operate effectively in a fast-paced evolving environment with competing priorities
  • Demonstrated ability to build collaborative relationships with internal and external
  • to travel up to 25% including occasional overnight and weekend travel
  • Positive team orientation with strong alignment to Dynes Core Values
  • Passion for improving the lives of patients with neuromuscular diseases

#LI-Onsite

MA Pay Range

$165000 - $190000 USD

The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education experience job-related knowledge and demonstrated skills.

The statements contained herein reflect general details as necessary to describe the principles functions for this job the level of knowledge and skill typically required and the scope of responsibility but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned including work in other functional areas to cover absences or relief to equalize peak work periods or otherwise balance workload.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age color disability gender national origin race religion sexual orientation veteran status or any classification protected by federal state or local law.


Required Experience:

Senior Manager


About Company

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Repairing muscle, reclaiming now. Life-transforming therapies for inherited muscle diseases.

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