Senior Manager, Biotherapeutics R&D

At Johnson & Johnsonwe believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented treated and curedwhere treatments are smarter and less invasive andsolutions are our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for more at .

As guided by Our Credo Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson we respect the diversity and dignity of our employees and recognize their merit.

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At Johnson & Johnson we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented treated and cured where treatments are smarter and less invasive and solutions are personal.

Through our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for humanity. Learn more at.

As guided by Our Credo Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson we respect the diversity and dignity of our employees and recognize their merit.

We are searching for the best talent for a Senior Manager Biotherapeutics R&D to be based on-site in Spring House PA.

Purpose:

We are seeking an accomplished scientific leader to define and advance our next-generation immunotherapy design strategy. Reporting to the Executive Director of Biologics Design and Function this role will shape scientific direction drive execution and identify differentiated therapeutic opportunities grounded in deep biological insight and translational relevance. This is not a project management role; it is an opportunity to tackle one of the most important unsolved challenges in biologics and build a new therapeutic capability for the company.

As a key scientific leader within our R&D organization the Senior Manager will help shape future research priorities with senior leadership deepen understanding of differentiated therapeutic concepts tied to critical patient needs identify and integrate emerging technologies and recruit develop and inspire exceptional scientific talent. The role also requires disciplined delivery against ambitious discovery pipeline goals balancing innovation scientific rigor and resource stewardship.

You will be responsible for:

• Own the scientific strategy and execution for next-generation platforms designed to create differentiated medicines across immunology oncology and adjacent disease areas.

• Lead multidisciplinary teams spanning discovery biology protein design/optimization translational sciences computational biology pharmacology and therapeutic area expertise to advance programs from concept through candidate selection.

• Drive the creation of novel therapeutic architectures that selectively recruit and program immune responses against disease-driving biology.

• Define and implement molecular strategies that enhance therapeutic activity while regulating biological response and expanding therapeutic index.

• Translate advances in immunology systems biology synthetic biology computational sciences and protein engineering into actionable therapeutic opportunities and platform capabilities.

• Maintain end-to-end ownership of scientific decisions that influence molecule performance differentiation strategy and long-term portfolio value.

• Identify and resolve critical biological and engineering bottlenecks affecting efficacy safety developability and translational potential.

• Convert complex and ambiguous scientific questions into executable research strategies measurable milestones and portfolio decisions.

• Drive rapid hypothesis generation experimental learning cycles and evidence-based decision-making across programs.

• Mentor and develop high-performing scientists while fostering a culture of scientific rigor curiosity accountability and bold thinking.

• Build teams that challenge assumptions and pursue bold ideas while maintaining strong execution discipline.

Qualifications:

Required

• PhD MD/PhD or equivalent in immunology cell biology molecular biology bioengineering or a related discipline.

• Typically 8 years of relevant research experience in biotechnology biopharma or leading translational academic environments.

• Deep expertise in immune cell biology and the mechanisms governing cellular activation signaling differentiation and functional response.

• Demonstrated success advancing biologic therapeutics from discovery through candidate selection.

• Strong understanding of translational pharmacology disease biology and mechanisms of therapeutic differentiation.

• Proven ability to lead multidisciplinary scientific teams in complex matrixed research environments.

Preferred

• Experience with multispecific therapeutic modalities immune-engaging platforms or engineered signaling systems.

• Expertise spanning multiple immune cell populations including innate and adaptive immune biology.

• Experience in mechanistic assay development human translational systems and biomarker strategy.

• Strong publication patent and/or drug discovery track record.

• Demonstrated ability to translate frontier science into differentiated therapeutic opportunities and platform value.

What Exceptional Candidates Often Bring

• The ability to connect first-principles biology with therapeutic design.

• Systems-level thinking rather than target-level thinking.

• Comfort operating where data are incomplete and scientific frameworks are still emerging.

• The ability to convert novel scientific concepts into scalable platforms and long-term portfolio value.

• The curiosity to pursue important questions not yet fully defined by the field.

Why This Role Matters

The future of medicine may depend not only on discovering individual targets but on learning how to direct biological systems with precision. This role will help define how immune systems can be programmed to recognize engage and eliminate disease while preserving the balance required for safe durable patient benefit.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federal state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation please email the Employee Health Support Center () or contact AskGS to be directed to your accommodation resource.

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