Senior Director, Protein Analytics & Biophysics

The Role:

Generate:Biomedicines is seeking a scientifically bold highly collaborative Senior Director to lead Protein Analytics & Biophysics within our Therapeutics division. This leader will set the vision for how Generate measures the biophysical biochemical and interaction properties of protein therapeutics across the design-build-test-learn cycle from conventional analytical characterization through next-generation pooled miniaturized and nanoscale measurement platforms.

We are looking for a field-leading biophysicist and platform builder who has not only operated best-in-class analytical and protein interaction workflows but has also invented scaled or industrialized new ways to measure protein therapeutic attributes at orders-of-magnitude higher throughput and lower sample consumption. The right person will be energized by the challenge of connecting micro- and nanoscale assay innovation with Generates AI/ML-enabled protein design engine.

This role will own the continued excellence of conventional protein analytics developability and protein-protein interaction technologies while building the next generation of at-scale experimental systems. The ideal candidate brings deep technical breadth a quantitative mindset and a clear point of view on how pooled assays DNA/barcode-enabled readouts synthetic biology automation microfluidics advanced detection and computational modeling can transform how protein therapeutics are evaluated.

Success in this role will require enterprise leadership: developing leaders and senior scientists building an inclusive and high-accountability culture partnering deeply across Protein Sciences Prototyping Technology Data Sciences Machine Learning Biology and CMC/Tech Ops and translating an ambitious scientific vision into robust capabilities that improve decision quality speed and scale.

Heres how you will contribute:

• Set and drive the multi-year scientific and organizational vision for Protein Analytics & Biophysics aligning functional strategy with Generates platform portfolio and company priorities.
• Define the next generation of biophysical biochemical developability and protein-protein interaction measurement capabilities for protein therapeutics with a particular focus on miniaturized pooled high-throughput and nanoscale approaches.
• Lead the continued evolution of conventional analytical and interaction workflows including HPLC/UPLC LC/MS electrophoretic thermal stability light scattering plate-based and biosensor-based platforms ensuring rigor reproducibility and decision relevance.
• Build a strategy that connects conventional analytical and biosensor technologies with emerging pooled or massively multiplexed approaches enabling Generate to measure protein attributes at scales that match the output of generative design.
• Partner with Prototyping Technology Automation Data Sciences Machine Learning Protein Sciences Biology and CMC/Tech Ops to design operationalize validate and scale new assay concepts into production-quality capabilities.
• Identify evaluate and implement external and internal technologies that can unlock smaller sample volumes richer attribute profiles higher throughput improved sensitivity or new classes of protein interaction and developability data.
• Establish data standards quality expectations assay controls and analytical frameworks that allow high-throughput measurements to be used confidently for model training candidate triage and program decision-making.
• Ensure the function generates high-quality decision-enabling data across Discovery Candidate Selection and early Development including developability stability specificity affinity kinetics and manufacturability-relevant attributes.
• Drive operational excellence across the function including prioritization resource planning milestone delivery metrics continuous improvement and clear communication of tradeoffs.
• Represent the function with executive stakeholders and external partners translating complex scientific strategy into clear compelling and actionable plans.

Leadership Responsibilities

• Lead as a strong people leader and culture builder who develops trust accountability scientific ambition and collaboration across a multidisciplinary organization.
• Build coach and develop a high-performing team of managers senior scientists and technical experts creating clear growth paths and succession strength within the function.
• Guide the team through transition with empathy and clarity while raising the technical bar for platform innovation cross-training and multidisciplinary biophysics.
• Foster an inclusive transparent and feedback-rich environment where individuals are empowered to take initiative share knowledge and continuously improve.
• Set a high bar for both technical excellence and partnership making collaboration across functions a visible standard for success.
• Partner effectively across functions to advance shared company goals.
• Develop leadership capability across the organization by mentoring managers growing future leaders and strengthening Generates broader scientific culture.
• Manage external collaborations CRO strategy academic relationships vendor partnerships and technology scouting efforts that increase scale speed and scientific differentiation.

The Ideal Candidate will have:

• Ph.D. in Biophysics Biochemistry Molecular Biology Chemical Biology Bioengineering Synthetic Biology Protein Engineering or a related scientific discipline; or equivalent depth of industry experience.
• 12yearsexperiencein biopharma biotechnology synthetic biology protein engineering or a related field with substantial leadership experience in protein analytics biophysics developability and protein-protein interaction characterization.
• Significant progressive experience in biopharma biotechnology synthetic biology protein engineering or a related field with substantial leadership experience in protein analytics biophysics developability and protein-protein interaction characterization.
• A track record of building inventing or scaling novel assay platforms for protein therapeutics especially miniaturized pooled multiplexed microfluidic barcode-enabled sequencing-enabled cell-based or nanoscale biophysical or biochemical measurements.
• Demonstrated ability to move beyond single-sample low-throughput paradigms and create experimental systems that generate high-dimensional quantitative data at the scale needed for AI/ML-enabled protein design.
• Deep technical expertise across conventional analytical and biophysical methods such as HPLC/UPLC (SEC RP HIC IEX) LC/MS CE-SDS cIEF DSF DSC DLS SEC-MALS SPR BLI and related technologies.
• Strong understanding of protein-protein interaction measurement including affinity kinetics specificity cross-reactivity epitope/binning avidity and context-dependent binding behavior.
• Strong quantitative mindset and experience using data quality assay statistics modeling and informatics to shape scientific strategy technology investment and operational decision-making.
• Experience partnering closely with prototyping automation engineering computational and technology teams to translate exploratory assay concepts into robust reproducible and scalable capabilities.
• Demonstrated success as a senior people leader including leading leaders developing senior scientific talent and scaling high-performing teams through periods of change.
• Exceptional collaboration and communication skills with a clear track record of influencing across complex matrixed organizations and engaging executive stakeholders with clarity candor and credibility.
• Experience advancing biologics programs across Discovery and early Development with an understanding of developability considerations candidate selection and downstream impact.
• Commitment to building an inclusive collaborative and high-accountability culture where people and science can thrive together.

Preferred / Nice to Have

• Experience creating platform capabilities that support machine learning-enabled discovery closed-loop experimental systems or large-scale design-build-test-learn cycles.
• Experience with pooled screening strategies DNA-encoded or barcode-linked readouts sequencing-based measurements display technologies high-throughput synthetic biology or massively multiplexed protein interaction datasets.
• Experience developing assays that require very low material input operate at micro- or nanoscale or integrate microfluidics acoustic dispensing advanced imaging high-content detection or next-generation automation.
• Experience serving as an external scientific spokesperson thought leader founder-like platform builder or conference presenter in biophysics protein analytics developability protein engineering or high-throughput interaction biology.
• Familiarity with regulatory expectations and analytical strategy in support of candidate selection and early development.

Who Will Love This Job:

This is an opportunity to define the future of biophysics at Generate:Biomedicines. You will lead an exceptional team at the intersection of biological engineering machine learning and medicine and you will shape how next-generation analytical and protein interaction technologies unlock scale insight and speed for our protein design platform. Your leadership will directly influence both the science we build and the culture we create.

About Generate:Biomedicines

We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creationone grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation this approach aims to reduce the uncertainty time and cost associated with developing protein-based medicines.

Founded in 2018 we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.

At Generate:Biomedicines we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need faster guided by our values and leadership behaviors.

Generate:Biomedicines is committed to equal employment opportunity regardless of race color ancestry religion sex national origin sexual orientation age citizenship marital status disability gender identity or Veteran status.

Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Companys internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

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