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Senior Bioinformatics Software Engineer

Guardant Health


Job Location:

Redwood City, CA - USA

Monthly Salary: $ 128700 - 176985
Posted: 2 June 2026 (30+ days ago)
Application Deadline: 14 September 2026
Vacancies: 1 Vacancy
The job posting is outdated and position may be filled

Job Summary

Company Description

Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012 Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care including screening to find cancer early monitoring for recurrence in early-stage cancer and treatment selection for patients with advanced cancer. For more information visitand follow the company onLinkedInX (Twitter)andFacebook.

Position Summary:
This role is in the Bioinformatics Software team you will be responsible for the software that is used in the clinical laboratory to process patient samples and analyze their genomic profiles finding the right treatment options for cancer patients based on a simple blood draw. You will participate in a small team following agile methodology. Your role would be to implement new solutions and architectures to solve complex problems in a clinical NGS setting creating new tooling and software solutions to deliver results to patients.

Essential Duties and Responsibilities:
Work with users and product managers to gather and refine requirements.
Maintain and extend the applications RESTful web service / APIs in Python.
Design and implement solutions end-end from user interface through persistent storage.
Provide written documentation and specifications of software products and services. Preferably in a regulated environment such as IVD or CLIA.
Ability to Verify and Validate software written according to SOP
Integrated use of LLM tools in all aspects of development from planning to execution.

Qualifications:
3-5 years experience developing software in production environment
Strong understanding of Python
Demonstrated knowledge and experience using object-oriented programming and design patterns in production environments
Working knowledge of FastAPI or other python API frameworks
Working knowledge of managing and deploying Docker images on a K8s environment
Experience working with a relational database preferably PostgreSQL
Effective communicator with written and verbal fluency in English.
Detail oriented with an initiative to drive tasks to completion.
Ability to work well in a rapid-pace environment
Ability to work well in a group and independently with minimal supervision
Demonstrable ability to perform the Essential Duties and Responsibilities of this position.


AI & Digital Fluency

  • Demonstrate curiosity sound judgment and the ability to critically evaluate and responsibly leverage AI-enabled tools in accordance with company policies ethical standards and regulatory requirements to improve the efficiency effectiveness and quality of work.


Hybrid Work Model: This section is applicable to onsite employees who are eligible for hybrid work location as specified by management and related policies. Guardant has defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays Tuesdays and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients.

The annualized base salary ranges for the primary location and any additional locations are listed below. This range does not include benefits or if applicable bonus commission or equity. Each candidates compensation offer will be based on multiple factors including but not limited to geography experience education job-related skills job duties and business need. Primary Location: Redwood City CA Primary Location Base Pay Range: $143000 - $196650 Other US Location(s) Base Pay Range: $121550 - $167153 If the role is performed in Colorado the pay range for this job is: $128700 - $176985


Employee may be required to lift routine office supplies and use office of the work is performed in a desk/office environment; however there may be exposure to high noise levels fumes and biohazard material in the laboratory to sit for extended periods of time.

Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities long-term conditions mental health conditions or sincerely held religious beliefs. If you need support please reach out to

A background screening including criminal history is required for this role. GH will consider qualified applicants with criminal arrest or conviction histories in a manner consistent with applicable law including but not limited to the LA County Fair Chance Policies and the Fair Chance Act (Gov. Code Section 12952).

Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity national origin or protected veteran status and will not be discriminated against on the basis of disability.

All your information will be kept confidential according to EEO guidelines.

To learn more about the information collected when you apply for a position at Guardant Health Inc. and how it is used please review ourPrivacy Notice for Job Applicants.

Please visit our career page at: Experience:

Senior IC


About Company

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Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary tests, vast data sets and advanced analytics. The Guardant Health oncology platform leverages capabilities to drive commercial adoption, improve patient cl ... View more

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