Scientist, Oncology Discovery (Multi-Specific Antibody Therapeutics)

Use Your Power for Purpose

At Pfizer our purpose is to deliver breakthroughs that change patients lives. Research and Development plays a critical role in turning cutting-edge science into innovative medicines. Within Pfizer Oncology we are advancing nextgeneration therapeutics to address areas of high unmet medical need for the benefit of patients globally.

What You Will Achieve

As a Scientist in the Discovery Technologies department you will contribute directly to earlystage programs focused on discovery of next generation biologics for oncology. Your work will generate high-impact functional screening data that guides antibody discovery decisions informs lead molecule selection and enables portfolio progression of transformative this role you will:

• Design develop and execute high-throughput cellbased functional assays in support of multispecific antibody and T cell engager discovery programs

• Perform assays measuring target engagement cell binding T cell-mediated cytotoxicity of tumor cells and T cell activation in the presence of antibody therapeutics; with flow cytometry luminescence NanoBRET and HTRF-based readouts

• Culture and maintain cancer cell lines and primary human T cells in vitro

• Generate and engineer cell lines using molecular cloning transfection lentivirus production and transduction

• Implement and support highthroughput and semiautomated assay workflows including use of Echo liquid handling systems and 384-well plate assay formats

• Analyze interpret and clearly communicate experimental data to project teams

• Effectively manage curate and structure experimental data to maintain high-quality documentation in electronic lab notebooks and enable integration with an AI-ready environment

• Collaborate effectively within crossfunctional teams spanning tumor biology protein engineering automation and data sciences

Here Is What You Need (Minimum Requirements)

• BS or MS in Biology Molecular Biology Cell Biology Biochemistry Immunology or a related discipline

• BA/BS with at least 6 years of experience or MBA/MS with at least 4 years of experience working with antibody-based therapeutics in biotechnology or pharmaceutical settings.

• Handson experience with cellbased functional assays particularly those assessing immune cell function (e.g. T cell cytotoxicity assays)

• Demonstrated proficiency in mammalian cell culture including cancer cell lines and primary immune cells

• Experience executing assays in highthroughput or semiautomated formats including familiarity with laboratory automation and 384-well plate assay formats

• Strong data analysis organization and documentation skills

• Excellent written and verbal communication skills and the ability to work productively in crossfunctional teams

• Ability to adapt quickly in a fastpaced discoverydriven research environment

Bonus Points If You Have (Preferred Requirements)

• Experience with molecular biology techniques including cloning transfection lentivirus production and cell line engineering

• Familiarity with biochemistry/biophysical analytical techniques used to characterize antibodies and other biologic therapeutics (SPR HPLC Mass spectrometry)

• Experience with Genedata platforms (Biologics Screener) or similar

PHYSICAL/MENTAL REQUIREMENTS

• Laboratory work requiring standing or sitting for extended periods

• Ability to work with biological samples and standard laboratory equipment

Other Job Details:

• Last Date to Apply for Job: June 1st 2026.

• Locations: USA - CA - San Diego (Torrey Heights)

• NOT eligible for Relocation Package

• This position is on premises and requires working onsite.

The annual base salary for this position ranges from $79400.00 to $132400.00. In addition this position is eligible for participation in Pfizers Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of lifes moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution paid vacation holiday and personal days paid caregiver/parental and medical leave and health benefits to include medical prescription drug dental and vision coverage. Learn more at Pfizer Candidate Site U.S. Benefits (). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN O-1 H-1B etc.) is not available for this role now or in the future.

Research and Development