Scientist – Off-Target Genomics (Gene Therapy)

We are seeking a Scientist Off-Target Genomics (Gene Therapy) to lead and execute genomic safety assessment strategies for gene editing therapeutics. This role focuses on evaluating off-target effects genomic integrity and emerging genome editing modalities.

Key Responsibilities:

• Lead genomic safety assessment packages including off-target discovery verification validation and genomic integrity characterization
• Apply and evaluate off-target discovery approaches using:
  • In silico tools (e.g. CALITAS CRISPRme Cas-OFFinder)
  • Biochemical methods (e.g. SITE-seq CIRCLE-seq CHANGE-seq Digenome-seq)
  • Cell-based assays (e.g. GUIDE-seq INDUCE-seq)
• Drive off-target confirmation using sequencing-based approaches such as AmpSeq rhAmpSeq and hybrid capture
• Assess genomic integrity using orthogonal platforms including karyotyping optical genome mapping and whole genome sequencing (WGS)
• Evaluate genotoxicity risks associated with next-generation genome editing technologies including base and prime editing
• Support and/or lead development of novel assays for emerging genome editing modalities (Gen 5)
• Integrate biodistribution data to inform tissue selection for off-target verification studies
• Collaborate cross-functionally and present findings clearly to scientific and project teams

Qualifications :

Minimum Qualifications:

• B.S. with 5 years M.S. with 37 years or Ph.D. with 24 years of industry experience in genomics molecular biology biochemistry or a related field
• Hands-on experience in off-target assessment and/or genomic safety evaluation for gene editing therapeutics
• Strong working knowledge of CRISPR-based genome editing technologies
• Experience with next-generation sequencing workflows and data interpretation
• Familiarity with base editing prime editing and associated genotoxicity considerations
• Demonstrated scientific problem-solving skills; assay development experience is a plus
• Strong communication skills with the ability to present complex data to diverse audiences
• Self-motivated adaptable and able to work both independently and collaboratively

Preferred Qualifications:

• Experience with optical genome mapping (e.g. Bionano platform)
• Understanding of regulatory expectations for genomic safety (IND/BLA submissions)
• Exposure to human diversity-informed off-target methods (e.g. ONE-seq)
• Authorization to work in the U.S. without sponsorship

Additional Information :

The position is Full Time Monday-Friday 8 am-5 pm. Candidates currently living within a commutable distance of Boston MA are encouraged to apply

What to Expect in the Hiring Process:

• 10-15 Minute Phone Interview with Regional Recruiter
• 45-60 Minute Virtual Interview with Manager and/or Group Leader
• 45-60 Minute In-Person Meeting for a Casual Discussion of the Role

What We Offer:

• Excellent full-time benefits including comprehensive medical coverage dental and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays
• Yearly goal-based bonus & eligibility for merit-based increases
• Annual Compensation is $104000 - $112320 depending on education and experience 

Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.

Remote Work :

No

Employment Type :

Full-time