Scientist l LBA (Ligand Binding Assay) Ops

We are seeking an independent knowledgeable and highly motivated Ligand Binding Assay Scientist (Scientist I) to join the Quantitative Translational and ADME Sciences (QTAS) department at Abbvie Bioresearch Center in Worcester MA.

The LBA Operations Bioanalytical team at ABC QTAS conducts non-regulated pre-clinical quantitative bioanalysis assays of large molecule therapeutics like monoclonal antibodies (mAb) multi-specific Abs antibody-drug conjugates (ADC) antibody oligonucleotide conjugates (AOCs) and fusion proteins for Pharmacokinetic (PK) Pharmacodynamic (PD) and Toxicokinetic (TK) studies using ligand binding assays to support early development and drug discovery efforts.

As a Scientist I you will be responsible for: 1) Conducting pre-clinical sample analysis using ligand binding assays (MSD ELISA) manually and using automated liquid handlers 2) Updating sample protocol and reagent management systems using electronic tools such as Laboratory Information Management System (rLIMS) and e-notebooks 3) Reporting discussing and QCing results to project teams which enable pharmacokinetic and pharmacodynamic analysis in support of oncology immunology neurology and other AbbVie therapeutic portfolios.

The ideal candidate will be a self-motivated highly adaptable scientist with strong attention to details has the ability to quickly learn new concepts and a commitment to clear consistent communication in a fast-paced dynamic environment.

Duties & Responsibilities:

• Analyze samples by ligand binding assays (PK PD TK ADA) using Meso Scale Discovery platform and colorimetric ELISA or other assay platforms.
• Plan and execute sample analysis based on bioanalytical protocols and in vivo study designs on a variety of biological matrices (tissue lysates serum others) from a variety of species (monkey mouse rat).
• Analyze pre-clinical in vivo samples based on a dynamically changing operational schedule.
• Interpret present and discuss assay results; use results to guide analysis and adjust strategy.
• Perform timely accurate and thorough data archiving in ELN and rLIMS.
• Communicate experimental plans and results effectively both verbally and in writing during regular lab meetings and with broader teams
• Actively support day-to-day laboratory operations.
• Write and update experimental protocols and procedures.
• Independently and efficiently initiate design interpret and troubleshoot operational assays.

Qualifications :

• Bachelors degree in biology biochemistry pharmacology or related field with at least 5 years of pharmaceutical experience or MS in mentioned fields with 2 years of relevant experience.
• Experience with ligand binding workflow and assay development and troubleshooting is required.
• Strong attention to detail with demonstrated impact as an independent and self-motivated contributor.
• Ability to operate and maintain laboratory equipment and reagents/material inventories independently.
• Experience with lab automation is desirable.
• Proven independence and problem-solving ability.
• Excellent written and verbal communication skills and ability to draft technical reports.
• Proficiency with computers and data analysis/documentation software including Excel LIMS and ELN.
• Ability to summarize communicate and interpret bioanalytical results.
• Ability and willingness to work effectively in a highly collaborative and multidisciplinary environment.

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this roleat  the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on manyfactors  including  geographic location and we may ultimately  pay more or less than the posted range. This range may be  modified in the future. 

• We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.

• This job is eligible to  participate in our short-term incentive programs.  

Note: No amount of pay is  considered to be wages or compensation until such amount isearned  vested  and determinable. The amount and availability of  any bonus commission incentive benefits or any other form of compensation and benefits that areallocable to a   particular employee  remains in the Companys sole and absolute discretion unless and until paid and may be  modified at the Companys sole and absolutediscretion  consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

US & Puerto Rico only - to learn more visit  & Puerto Rico applicants seeking a reasonable accommodation click here to learn more:

Work :

No

Employment Type :

Full-time