Scientist III Bioconjugation

The Scientist I/II will be an integral member of the Targeted Therapeutics Group focused on generating novel antibody-based therapies for the treatment of cancers. The successful candidate will contribute to the design synthesis characterization and optimization of antibody-drug conjugates (ADCs) degrader-antibody conjugates (DACs) and other targeted therapeutic modalities. This position offers an exciting opportunity to work in a fast-paced multidisciplinary environment advancing innovative cancer therapeutics from discovery through preclinical development and into clinical development.

Responsibilities and Job Duties:

• Design and execute antibody conjugation experiments using a variety of linker-payload technologies.
• Develop and optimize bioconjugation processes for ADCs DACs and related targeted therapeutics.
• Synthesize and optimize novel linker-payload molecules directly contributing to next-generation ADC therapies.
• Purify characterize and analyze synthesized molecules using analytical techniques such as HPLC FPLC LC-MS and NMR.
• Evaluate conjugation efficiency drug-to-antibody ratio (DAR) aggregation stability and product quality attributes.
• Contribute to troubleshooting process optimization and scale-up activities.
• Collaborate closely with cross-functional teams to advance ADC programs from early discovery through preclinical and clinical development stages.
• Author protocols research reports and intellectual property documents while maintaining high-quality electronic laboratory records

Minimum Qualifications

Education & Experience

Scientist I

• M.S. degree in Chemistry Biochemistry Chemical Biology Pharmaceutical Sciences or a related field with 0-2 years of direct relevant experience.
• B.S. degree in Chemistry Biochemistry Chemical Biology Pharmaceutical Sciences or a related field with 3-5 years of direct relevant experience.

Scientist II

• M.S. degree in Chemistry Biochemistry Chemical Biology Pharmaceutical Sciences or a related field with 2-5 years of direct relevant experience.
• B.S. degree in Chemistry Biochemistry Chemical Biology Pharmaceutical Sciences or a related field with 5-8 years of direct relevant experience.

Knowledge Skills and Abilities

• Hands-on experience in bioconjugation protein conjugation or antibody-drug conjugate development.
• Experience with purification and characterization techniques for both small molecules and bioconjugates.
• Strong understanding of protein chemistry antibody structure and conjugation methodologies.
• Experience operating analytical instruments such as HPLC UPLC LC-MS SEC and HIC.
• Excellent organizational documentation and communication skills.
• Ability to work independently while contributing effectively within cross-functional teams.
• Detail-oriented and well organized with strong written and verbal communication skills.

Preferred Qualifications

• Experience developing ADCs DACs or other targeted therapeutic modalities.
• Familiarity with linker-payload chemistry site-specific conjugation and cysteine-based conjugation strategies.
• Experience with analytical analysis of conjugates: DAR aggregation and stability of conjugates.
• Experience in synthetic organic chemistry including the synthesis purification and characterization of small molecules and linker-payloads.

Supervisory Responsibilities

• None

Additional Information

The annual rate of pay for this position ranges from $86100 - $131300 for Scientist I and $95900 - $146300 for Scientist II. For non-exempt roles and according to applicable regulations there may be the possibility for overtime pay. This role is eligible for the Companys discretionary bonus and discretionary equity incentives. Eligible employees may participate in the Companys benefits programs including medical / dental / vision / prescription coverage employee wellness resources 401(k) plan with employer match access to an Employee Stock Purchase Plan (ESPP) paid time off & paid parental leave benefits and disability benefits.

The annual pay rate range is described in good faith and the Company believes is the range of possible compensation for this role at the time of this posting depending on the candidates experience qualifications geographic location and other factors permitted by law. The Company may ultimately pay more or less than the posted range and this range may be modified in the future. No amount is considered to be wages or compensation until such amount is earned vested and determinable under the terms and conditions of the applicable policies and plans. The amount and availability of any bonus commission benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole discretion unless and until paid and may be modified at the Companys sole discretion consistent with the law.

Statement

MacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race color national origin sex gender identity sexual orientation religion age disability protected veteran status or any other characteristic protected by federal state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If because of a medical condition or disability you need a reasonable accommodation for any part of the employment process please email or call and/or 711 for TTD/TTY service.

Required Experience:

IC