Scientist II – Oligonuleotide Synthesis

Our client a world leader in biotechnology and gene therapy is looking for an Scientist II Oligonuleotide Synthesis based in South San Francisco CA.

Job Duration: Long Term Contract (Possibility Of Extension)

Pay Rate : $53/hr on W2

Company Benefits: Medical Dental Vision Paid Sick leave 401K

We are seeking a Scientist II to join the Nucleic Acid Design and Discovery (NADD) team. This role focuses on oligonucleotide therapeutics discovery supporting RNAi-based research through synthesis characterization and collaboration across therapeutic areas.

Key Responsibilities

• Design and execute oligonucleotide synthesis and purification workflows.
  
• Perform HPLC and mass spectrometry analysis for characterization and impurity profiling.
  
• Support RNAi and nucleic acid therapeutic discovery across neuroscience immunology and oncology programs.
  
• Develop and scale up synthesis of lead oligonucleotide candidates for preclinical studies.
  
• Collaborate with cross-functional teams to integrate chemistry and biology data.
  
• Maintain and troubleshoot lab equipment (e.g. oligo synthesizers HPLC systems).
  
• Conduct literature reviews and contribute to experimental design and strategy.
  

Qualifications:

• BS/MS in Organic Chemistry or related field.
  
• Hands-on experience with oligonucleotide synthesis purification and characterization.
  
• Experience with automated oligo synthesizers HPLC and mass spectrometry.
  
• Understanding of RNAi nucleic acid therapeutics and modification chemistries preferred.
  
• Industry experience in biotech/pharma R&D is a plus.
  

If interested please send us your updated resume at

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