Scientist II, Assay Operations, Screening Platform Technologies

Revolution Medicines is a global commercial-state oncology company dedicated to discovering developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform the company is advancing a broad integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active cancer-driving state of on rigorous scientific inquiry and a willingness to challenge long-held assumptions Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science challenge assumptions act with urgency and hold ourselves to a high standard of rigorall in service of patients.

The Opportunity:

We are seeking a Scientist II Assay Operations Screening Platform Technologies (SPT) to support and scale next-generation cellular screening capabilities for oncology drug discovery. This role will focus on assay operations screening execution automation enablement and assay scale-up to support high-throughput and high-content screening campaigns across early discovery and lead optimization programs.

The successful candidate will partner closely with cross-functional collaborators across Discovery Sciences Cancer Biology Automation Data Science and external partners to establish robust scalable and operationally efficient screening workflows. This position is ideal for a scientist with strong experience executing and operationalizing cellular assays who enjoys working at the intersection of biology automation and screening infrastructure.

In this role you will support the transfer optimization execution and scaling of cellular assays across multiple screening platforms helping ensure assays are automation-ready reproducible and fit for high-throughput applications. You will contribute to the implementation of standardized workflows assay quality control processes instrumentation integration and operational best practices that enable efficient data generation across internal and external screening activities.

The ideal candidate is a highly collaborative and detail-oriented experimentalist with hands-on experience in assay operations liquid handling automation and screening logistics. They will thrive in a fast-paced environment enjoy troubleshooting technical challenges and contribute to building scalable screening infrastructure that accelerates oncology discovery efforts.

Responsibilities

• Optimize productionalize validate and execute robust screening assays across various cellular screening formats (e.g. CellTiter-Glo NanoBRET imaging-based and transcriptomic readouts).

• Lead and support execution of high-throughput and medium-throughput screening campaigns using automated liquid handling and integrated instrumentation platforms.

• Coordinate assay transfer activities internally and externally including protocol standardization reagent qualification documentation and execution support.

• Develop and implement workflows for quantitative scalable profiling in support of oncology programs.

• Contribute to experimental design discussions and data review for projects involving molecular glue characterization and protein interaction modulation.

• Apply advanced data analysis methods integrating tools such as Genedata Screener D360 Spotfire and programming languages (Python R) to derive actionable insights from complex assay outputs.

• Coordinate and manage tech transfer to external CROs ensuring quality execution of high-throughput screens and phenotypic assays.

• Collaborate within SPT and across functions Med Chem Cancer Biology Bioinformatics Automation to ensure cohesive project execution and data flow.

• Manage timelines and deliverables for multiple projects simultaneously maintaining high standards for scientific rigor and project communication.

• Support training and mentorship of junior team members while contributing to the collaborative and mission-driven culture of SPT.

Required Skills Experience and Education:

• PhD in biological sciences chemical biology pharmacology or bioengineering with 24 years of relevant experience; or MS with 58 years of experience in industry or biotech settings.

• Demonstrated expertise in assay development and optimization for high-throughput and/or high-content screening platforms.

• Working knowledge of assay performance metrics and screening QC parameters (Z signal/background CVs normalization strategies).

• Proficiency with data analysis and visualization tools such as Genedata Screener Spotfire D360 Excel or related platforms for large complex data sets

• Robust experience with cell based assay development and cell based or phenotypic screening.

• Hands-on experience using automation platforms (e.g. Hamilton Dragonfly Echo Mosquito) and familiarity with scheduling software for walk-up and integrated systems.

• Proven ability to manage and coordinate external CRO partnerships for assay execution and data delivery.

• Excellent organizational and project management skills with the ability to prioritize and balance multiple efforts concurrently.

• Experience supporting phenotypic mechanistic or oncology-focused screening assays.

• Excellent communication skills with a collaborative team-oriented mindset and a strong sense of scientific ownership.

Preferred Skills:

• Familiarity with automated liquid handling (SPT Dragonfly and/or Mosquito Agilent Bravo Tecan)

• Experience with high throughput screening and comfortabiity leveraging automation and AI/ML to support.

• Facile with instrumentation able to trouble shoot problems and work with engineers to generate successful solutions to technical limitations.

• Rigorous quantitative detail-oriented experimentalist with an understanding of statistics.

Who You Are:

• Deeply analytical and curiousexcited by data-driven discovery and uncovering patterns in complex biological systems.

• Energized by working at the interface of technology and biology to solve challenging problems in oncology drug discovery.

• Proactive and adaptableable to thrive in a fast-paced evolving environment with high expectations for quality and impact.

• Committed to mentorship collaboration and scientific excellence in pursuit of transformative therapies for patients.

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