Scientist I

Scientist I
South San Francisco CA
12 Months

Working Model: onsite (five days a week)
Working days: Monday through Friday
Working hours (e.g. 8 AM to 4 PM PT 9 AM to 5 PM etc.): Standard 8 hours
Interview Format (e.g. 1-2 rounds of virtual interviews)

Position Summary

We are seeking a highly motivated and skilled Scientist to join our Biochemical and Cellular Pharmacology Department. This hands-on laboratory-based role focuses on the development and execution of induced proximity-based assays crucial for the discovery and validation of Client therapeutic compounds. The successful candidate will work at the heart of a multi-disciplinary environment translating experimental data into actionable insights for our drug discovery programs.

In this role the candidate will have the unique opportunity to pioneer new induced-proximity approaches and help shape the scientific direction of early-stage drug-discovery programs.

Key Responsibilities

• Assay Development: Design and develop biochemical and cell-based assays for quantitative measurement of proteinprotein and proteinsmall molecule interactions.
• Screening & Validation: Conduct routine screening and deep-dive validation studies to support lead identification and optimization.
• Data Analysis: Perform rigorous analysis of complex data sets ensuring high quality and reproducibility.
• Cross-Functional Collaboration: Partner effectively with colleagues in Pharmacology Protein Science Medicinal Chemistry and Research Biology.
• Communication: Prepare technical reports and present findings clearly during multi-disciplinary project team meetings.

Education & Experience

• Degree: B.S. or M.S. in Biochemistry Biophysics Cellular/Molecular Biology or a related scientific discipline.
• Experience: 13 years of hands-on laboratory experience within an academic biotechnology or pharmaceutical industry setting.

Mandatory Skiils Requirements

• Demonstrated experience designing developing validating and executing cellular and biochemical assays supported by a strong theoretical and practical understanding of biochemistry and biophysics relevant to complex protein systems.
• Direct experience with induced proximity assays and modalities (molecular glues bivalent degraders ternary complexes and multicomponent binding systems).
• Proficiency with data analysis methods and specialized software. Ability to move beyond default vendor fits and analyze complex system behavior using Prism Python R or comparable tools.
• Proven ability to critically analyze and interpret complex data sets troubleshoot experimental hurdles and a proactive interest in adopting new technologies.

Preferred Technical Skills (Advantageous)

• Experience with protein biochemistry recombinant protein expression and molecular biology methods (e.g. western blot cell culture cell growth assays).
• Experience with nanoBRET nanoBiT TR-FRET BRET as well as imaging-based approaches.
• Familiarity with automated or semi-automated laboratory instrumentation (e.g. liquid handlers plate washers).
• Ability to thrive in a fast-paced dynamic environment and remain productive through shifting priorities or project changes.
• Proven ability to work effectively as part of a high-functioning multi-disciplinary team.
• A proactive approach to troubleshooting and a keen interest in learning new technologies as project needs evolve.

Why TalentBurst
At TalentBurst we deliver more than talent we deliver outcomes. We partner with you to move quickly and connect you to opportunities aligned with your skills and long term growth.

Backed by precision transparency and results we connect top talent with leading organizations through trusted partnerships.

We offer competitive compensation and comprehensive benefits including medical dental vision and retirement options.

TalentBurst is an equal opportunity employer committed to an inclusive and diverse workforce.