Scientist I, Functional Bioassay & High-Throughput Screening

The Role:

The Functional Bioassay team is seeking a Scientist I Functional Bioassay / High-Throughput Screening to support the development optimization and execution of functional assays across Generates growing portfolio of therapeutic programs. This is a bench-focused role for a scientist who enjoys hands-on experimental work and wants to contribute directly to the generation of high-quality functional data at scale that informs AI/ML-enabled protein therapeutic design and program decisions.

The successful candidate will support and where appropriate design optimize and troubleshoot biochemical and cell-based assays; execute high-throughput screening campaigns; analyze assay data; and help integrate automation into HTS workflows across multiple program areas. Key areas of focus may include ion channel GPCR ADC-related functional HTS assays and other cell-based or biochemical screening platforms as portfolio needs evolve.

This role is expected to be approximately 8090% laboratory-based and will require close collaboration with scientists across the Therapeutics organization Data Science research leads automation colleagues and cross-functional program teams to accelerate closed-loop experimental cycles. The scientist will help advance platform-wide innovation in assay execution data quality automation onboarding and workflow scalability.

This position is well-suited for an early-career scientist with strong technical skills curiosity to learn new assay systems clear communication skills and a desire to grow in a fast-paced collaborative biotech environment while contributing meaningfully to therapeutic discovery programs.

Heres how you will contribute:

• Design optimize and implement HTS-compatible biochemical and cell-based assays with appropriate integration of automation.
• Execute plate-based HTS campaigns analyze results and interpret complex experimental datasets.
• Clearly communicate findings to program teams to support AI/ML-enabled design cycles program prioritization and iterative therapeutic optimization.
• Support multiple therapeutic programs as a functional assay contributor with potential focus areas including ion channel GPCR and ADC-related assays.
• Learn and apply new assay technologies including ion channel and GPCR functional assays with guidance from senior team members and internal or external subject matter experts as needed.
• Perform laboratory experiments with attention to detail scientific rigor and adherence to established protocols.
• Troubleshoot assay performance instrumentation reagent or workflow issues in partnership with senior scientists and automation colleagues.
• Maintain accurate timely and well-organized records in electronic laboratory notebooks and other data systems.
• Prepare clear summaries of experimental results for internal team discussions program updates and cross-functional meetings.
• Collaborate with colleagues across Functional Bioassay Automation Biology Protein Sciences Data Science and program teams to ensure experiments are well coordinated and aligned with project needs.
• Follow laboratory safety practices sample handling requirements data integrity expectations and Generates scientific standards.

The Ideal Candidate will have:

• PhD in cell biology pharmacology immunology biochemistry bioengineering molecular biology or a related discipline with relevant hands-on laboratory experience; orMSc with approximately 4 years of relevant industry or academic research experience; or BSc with approximately 6 years of relevant industry or academic research experience
• Hands-on experience with cell-based biochemical or functional assays in an academic biotech pharmaceutical or related research setting.
• Strong technical foundation in mammalian cell culture and plate-based assay workflows.
• Experience executing experiments with careful attention to controls replicates data quality and documentation.
• Experience with ELISA HTRF AlphaLISA luminescence/fluorescence assays flow cytometry or similar assay technologies.
• Familiarity with high-throughput or medium-throughput screening workflows including multiwell plate formats.
• Ability to follow established protocols while recognizing when assay performance data quality or experimental results require troubleshooting.
• Comfort working in a fast-paced matrixed research environment where priorities may shift across multiple programs.
• Strong organizational skills and the ability to manage several experiments or workstreams with guidance from a manager or senior colleagues.
• Ability to analyze and present data clearly using tools such as GraphPad Prism ScreenWorks Harmony iQue Forecyt Spotfire or similar platforms.
• Strong written and verbal communication skills including the ability to summarize experimental results observations and next steps clearly
• Collaborative working style accountability curiosity adaptability and willingness to learn new assay formats therapeutic areas and technologies.

Nice to Have

• Experience with ion channel assays or related functional readouts such as electrophysiology-adjacent workflows membrane potential assays or thallium flux assays.
• Experience with GPCR assays including reporter assays calcium flux assays cAMP assays beta-arrestin assays or other pathway-based functional assays.
• Experience with ADC image-based internalization targeted protein degradation immune cell or cytotoxicity assay formats.
• Experience working with primary cells engineered cell lines or stable cell line generation.
• Experience with lab automation systems such as HighRes Beckman Biomek i5/i7 Hamilton EL406 Multidrop or equivalent liquid handling platforms.
• Experience working in a biotech or pharmaceutical research environment and/or interest in applying functional biology to AI/ML-enabled therapeutic discovery.

About Generate Biomedicines

We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creationone grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation this approach aims to reduce the uncertainty time and cost associated with developing protein-based medicines.

Founded in 2018 we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.

At Generate:Biomedicines we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need faster guided by our values and leadership behaviors.

Generate:Biomedicines is committed to equal employment opportunity regardless of race color ancestry religion sex national origin sexual orientation age citizenship marital status disability gender identity or Veteran status.

Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Companys internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

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